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Extrachromosomal circular DNA: Current status and future prospects

Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on...

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Detalles Bibliográficos
Autores principales: Zhao, Yiheng, Yu, Linchan, Zhang, Shuchen, Su, Xiangyu, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578701/
https://www.ncbi.nlm.nih.gov/pubmed/36256570
http://dx.doi.org/10.7554/eLife.81412
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author Zhao, Yiheng
Yu, Linchan
Zhang, Shuchen
Su, Xiangyu
Zhou, Xiang
author_facet Zhao, Yiheng
Yu, Linchan
Zhang, Shuchen
Su, Xiangyu
Zhou, Xiang
author_sort Zhao, Yiheng
collection PubMed
description Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell phenotypes. In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application. Thus, with the deepening of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application.
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spelling pubmed-95787012022-10-19 Extrachromosomal circular DNA: Current status and future prospects Zhao, Yiheng Yu, Linchan Zhang, Shuchen Su, Xiangyu Zhou, Xiang eLife Medicine Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell phenotypes. In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application. Thus, with the deepening of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application. eLife Sciences Publications, Ltd 2022-10-18 /pmc/articles/PMC9578701/ /pubmed/36256570 http://dx.doi.org/10.7554/eLife.81412 Text en © 2022, Zhao et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Medicine
Zhao, Yiheng
Yu, Linchan
Zhang, Shuchen
Su, Xiangyu
Zhou, Xiang
Extrachromosomal circular DNA: Current status and future prospects
title Extrachromosomal circular DNA: Current status and future prospects
title_full Extrachromosomal circular DNA: Current status and future prospects
title_fullStr Extrachromosomal circular DNA: Current status and future prospects
title_full_unstemmed Extrachromosomal circular DNA: Current status and future prospects
title_short Extrachromosomal circular DNA: Current status and future prospects
title_sort extrachromosomal circular dna: current status and future prospects
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578701/
https://www.ncbi.nlm.nih.gov/pubmed/36256570
http://dx.doi.org/10.7554/eLife.81412
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AT suxiangyu extrachromosomalcirculardnacurrentstatusandfutureprospects
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