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Extrachromosomal circular DNA: Current status and future prospects
Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578701/ https://www.ncbi.nlm.nih.gov/pubmed/36256570 http://dx.doi.org/10.7554/eLife.81412 |
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author | Zhao, Yiheng Yu, Linchan Zhang, Shuchen Su, Xiangyu Zhou, Xiang |
author_facet | Zhao, Yiheng Yu, Linchan Zhang, Shuchen Su, Xiangyu Zhou, Xiang |
author_sort | Zhao, Yiheng |
collection | PubMed |
description | Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell phenotypes. In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application. Thus, with the deepening of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application. |
format | Online Article Text |
id | pubmed-9578701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-95787012022-10-19 Extrachromosomal circular DNA: Current status and future prospects Zhao, Yiheng Yu, Linchan Zhang, Shuchen Su, Xiangyu Zhou, Xiang eLife Medicine Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell phenotypes. In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application. Thus, with the deepening of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application. eLife Sciences Publications, Ltd 2022-10-18 /pmc/articles/PMC9578701/ /pubmed/36256570 http://dx.doi.org/10.7554/eLife.81412 Text en © 2022, Zhao et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Medicine Zhao, Yiheng Yu, Linchan Zhang, Shuchen Su, Xiangyu Zhou, Xiang Extrachromosomal circular DNA: Current status and future prospects |
title | Extrachromosomal circular DNA: Current status and future prospects |
title_full | Extrachromosomal circular DNA: Current status and future prospects |
title_fullStr | Extrachromosomal circular DNA: Current status and future prospects |
title_full_unstemmed | Extrachromosomal circular DNA: Current status and future prospects |
title_short | Extrachromosomal circular DNA: Current status and future prospects |
title_sort | extrachromosomal circular dna: current status and future prospects |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578701/ https://www.ncbi.nlm.nih.gov/pubmed/36256570 http://dx.doi.org/10.7554/eLife.81412 |
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