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Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs. Many drugs target secreted ligands and their cell surface receptors. Still, there are hundr...

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Detalles Bibliográficos
Autores principales:	Siepe, Dirk H, Henneberg, Lukas T, Wilson, Steven C, Hess, Gaelen T, Bassik, Michael C, Zinn, Kai, Garcia, K Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578707/ https://www.ncbi.nlm.nih.gov/pubmed/36178190 http://dx.doi.org/10.7554/eLife.81398

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