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Cytotoxicity of Hybrid Noble Metal-Polymer Composites
The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578826/ https://www.ncbi.nlm.nih.gov/pubmed/36267838 http://dx.doi.org/10.1155/2022/1487024 |
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author | Tkachenko, Anton Virych, Pavlo Myasoyedov, Valeriy Prokopiuk, Volodymyr Onishchenko, Anatolii Butov, Dmytro Kuziv, Yuliia Yeshchenko, Oleg Zhong, Sican Nie, Guochao Kutsevol, Nataliya |
author_facet | Tkachenko, Anton Virych, Pavlo Myasoyedov, Valeriy Prokopiuk, Volodymyr Onishchenko, Anatolii Butov, Dmytro Kuziv, Yuliia Yeshchenko, Oleg Zhong, Sican Nie, Guochao Kutsevol, Nataliya |
author_sort | Tkachenko, Anton |
collection | PubMed |
description | The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca(2+)-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays. |
format | Online Article Text |
id | pubmed-9578826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95788262022-10-19 Cytotoxicity of Hybrid Noble Metal-Polymer Composites Tkachenko, Anton Virych, Pavlo Myasoyedov, Valeriy Prokopiuk, Volodymyr Onishchenko, Anatolii Butov, Dmytro Kuziv, Yuliia Yeshchenko, Oleg Zhong, Sican Nie, Guochao Kutsevol, Nataliya Biomed Res Int Research Article The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca(2+)-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays. Hindawi 2022-10-11 /pmc/articles/PMC9578826/ /pubmed/36267838 http://dx.doi.org/10.1155/2022/1487024 Text en Copyright © 2022 Anton Tkachenko et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tkachenko, Anton Virych, Pavlo Myasoyedov, Valeriy Prokopiuk, Volodymyr Onishchenko, Anatolii Butov, Dmytro Kuziv, Yuliia Yeshchenko, Oleg Zhong, Sican Nie, Guochao Kutsevol, Nataliya Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title | Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title_full | Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title_fullStr | Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title_full_unstemmed | Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title_short | Cytotoxicity of Hybrid Noble Metal-Polymer Composites |
title_sort | cytotoxicity of hybrid noble metal-polymer composites |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578826/ https://www.ncbi.nlm.nih.gov/pubmed/36267838 http://dx.doi.org/10.1155/2022/1487024 |
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