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Cytotoxicity of Hybrid Noble Metal-Polymer Composites

The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy....

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Autores principales: Tkachenko, Anton, Virych, Pavlo, Myasoyedov, Valeriy, Prokopiuk, Volodymyr, Onishchenko, Anatolii, Butov, Dmytro, Kuziv, Yuliia, Yeshchenko, Oleg, Zhong, Sican, Nie, Guochao, Kutsevol, Nataliya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578826/
https://www.ncbi.nlm.nih.gov/pubmed/36267838
http://dx.doi.org/10.1155/2022/1487024
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author Tkachenko, Anton
Virych, Pavlo
Myasoyedov, Valeriy
Prokopiuk, Volodymyr
Onishchenko, Anatolii
Butov, Dmytro
Kuziv, Yuliia
Yeshchenko, Oleg
Zhong, Sican
Nie, Guochao
Kutsevol, Nataliya
author_facet Tkachenko, Anton
Virych, Pavlo
Myasoyedov, Valeriy
Prokopiuk, Volodymyr
Onishchenko, Anatolii
Butov, Dmytro
Kuziv, Yuliia
Yeshchenko, Oleg
Zhong, Sican
Nie, Guochao
Kutsevol, Nataliya
author_sort Tkachenko, Anton
collection PubMed
description The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca(2+)-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.
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spelling pubmed-95788262022-10-19 Cytotoxicity of Hybrid Noble Metal-Polymer Composites Tkachenko, Anton Virych, Pavlo Myasoyedov, Valeriy Prokopiuk, Volodymyr Onishchenko, Anatolii Butov, Dmytro Kuziv, Yuliia Yeshchenko, Oleg Zhong, Sican Nie, Guochao Kutsevol, Nataliya Biomed Res Int Research Article The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca(2+)-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays. Hindawi 2022-10-11 /pmc/articles/PMC9578826/ /pubmed/36267838 http://dx.doi.org/10.1155/2022/1487024 Text en Copyright © 2022 Anton Tkachenko et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tkachenko, Anton
Virych, Pavlo
Myasoyedov, Valeriy
Prokopiuk, Volodymyr
Onishchenko, Anatolii
Butov, Dmytro
Kuziv, Yuliia
Yeshchenko, Oleg
Zhong, Sican
Nie, Guochao
Kutsevol, Nataliya
Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title_full Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title_fullStr Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title_full_unstemmed Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title_short Cytotoxicity of Hybrid Noble Metal-Polymer Composites
title_sort cytotoxicity of hybrid noble metal-polymer composites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578826/
https://www.ncbi.nlm.nih.gov/pubmed/36267838
http://dx.doi.org/10.1155/2022/1487024
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