Cargando…

The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moorey, Alice R., Besra, Gurdyal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578982/ https://www.ncbi.nlm.nih.gov/pubmed/36277080 http://dx.doi.org/10.1016/j.tcsw.2022.100083

Ejemplares similares

Transmembrane Protein 68 Functions as an MGAT and DGAT Enzyme for Triacylglycerol Biosynthesis
por: Wang, Yu, et al.
Publicado: (2023)

Triacylglycerols: Fuelling the Hibernating Mycobacterium tuberculosis
por: Maurya, Rahul Kumar, et al.
Publicado: (2019)

Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall
por: Batt, Sarah M., et al.
Publicado: (2020)

Overexpression of DGAT2 Stimulates Lipid Droplet Formation and Triacylglycerol Accumulation in Bovine Satellite Cells
por: Zhang, Jun-Fang, et al.
Publicado: (2022)

Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2
por: Xu, Jingyu, et al.
Publicado: (2012)

Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction
por: Mishra, Arun K, et al.
Publicado: (2011)

Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase
por: Alderwick, Luke J, et al.
Publicado: (2011)

Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars
por: Fullam, Elizabeth, et al.
Publicado: (2016)

The Utilization of the Acyl-CoA and the Involvement PDAT and DGAT in the Biosynthesis of Erucic Acid-Rich Triacylglycerols in Crambe Seed Oil
por: Furmanek, Tomasz, et al.
Publicado: (2014)

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
por: Trunkfield, Amy E., et al.
Publicado: (2010)

Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis
por: Harrison, James, et al.
Publicado: (2016)

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
por: Moorey, Alice R., et al.
Publicado: (2021)

Novel Treatments against Mycobacterium tuberculosis Based on Drug Repurposing
por: Mourenza, Álvaro, et al.
Publicado: (2020)

Repurposing Cefazolin-Avibactam for the Treatment of Drug Resistant Mycobacterium tuberculosis
por: Srivastava, Shashikant, et al.
Publicado: (2021)

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation
por: Cox, Jonathan A. G., et al.
Publicado: (2019)

An Acyl-CoA Synthetase in Mycobacterium tuberculosis Involved in Triacylglycerol Accumulation during Dormancy
por: Daniel, Jaiyanth, et al.
Publicado: (2014)

Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors
por: Muise, Eric S., et al.
Publicado: (2014)

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
por: Chitraju, Chandramohan, et al.
Publicado: (2019)

Generation of Liposomes to Study the Effect of Mycobacterium Tuberculosis Lipids on HIV-1 cis- and trans-Infections
por: Pouget, Marion, et al.
Publicado: (2021)

Identification and Repurposing of Trisubstituted Harmine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis Phosphoserine Phosphatase
por: Pierson, Elise, et al.
Publicado: (2020)

Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis
por: Gómez-Velasco, Anaximandro, et al.
Publicado: (2013)

A Chemical Proteomics Approach to Profiling the ATP-binding Proteome of Mycobacterium tuberculosis
por: Wolfe, Lisa M., et al.
Publicado: (2013)

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis
por: Usha, Veeraraghavan, et al.
Publicado: (2012)

Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg(2+)
por: Brown, Alistair K, et al.
Publicado: (2007)

The olive DGAT2 gene is developmentally regulated and shares overlapping but distinct expression patterns with DGAT1
por: Banilas, Georgios, et al.
Publicado: (2011)

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach
por: Soto, Ramón, et al.
Publicado: (2018)

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module
por: Alderwick, Luke J., et al.
Publicado: (2011)

Identification of an α(1→6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis
por: Mishra, Arun K, et al.
Publicado: (2007)

The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function
por: Roe, Nathan D., et al.
Publicado: (2018)

Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells
por: Matsunaga, Isamu, et al.
Publicado: (2004)

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis
por: Sambandan, Dhinakaran, et al.
Publicado: (2013)

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis
por: Grover, Shipra, et al.
Publicado: (2020)

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis
por: Kendall, Sharon L, et al.
Publicado: (2007)

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen
por: Cox, Jonathan A. G., et al.
Publicado: (2016)

Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC
por: Karlikowska, Magdalena, et al.
Publicado: (2021)

Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2
por: Irshad, Zehra, et al.
Publicado: (2019)

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
por: Batt, Sarah M., et al.
Publicado: (2023)

Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors
por: Hong, Dong Jin, et al.
Publicado: (2019)

Phosphorylation and function of DGAT1 in skeletal muscle cells
por: Yu, Jinhai, et al.
Publicado: (2015)

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis
por: Jankute, Monika, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ubiiqc3c2g2p6727tek77jo6it