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D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia

Degeneration of dopaminergic neurons leads to Parkinson’s disease (PD), characterized by reduced levels of striatal dopamine (DA) and impaired voluntary movements. DA replacement is achieved by levodopa treatment which in long-term causes involuntary movements or dyskinesia. Dyskinesia is linked to...

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Detalles Bibliográficos
Autores principales:	Florio, Ermanno, Serra, Marcello, Lewis, Robert G., Kramár, Enikö, Freidberg, Michael, Wood, Marcello, Morelli, Micaela, Borrelli, Emiliana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579025/ https://www.ncbi.nlm.nih.gov/pubmed/36274959 http://dx.doi.org/10.1016/j.isci.2022.105263

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