Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing

Classical swine fever virus (CSFV), a classic swine fever pathogen, causes severe economic losses worldwide. Poly (rC)-binding protein 1 (PCBP1), which interacts with N(pro) of CSFV, plays a vital role in CSFV growth. We are the first to report the generation of PCBP1-deficient pigs via gene-editing...

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Detalles Bibliográficos
Autores principales: Qi, Chunyun, Pang, Daxin, Yang, Kang, Jiao, Shuyu, Wu, Heyong, Zhao, Chuheng, Hu, Lanxin, Li, Feng, Zhou, Jian, Yang, Lin, Lv, Dongmei, Tang, Xiaochun, Ouyang, Hongsheng, Xie, Zicong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579030/
https://www.ncbi.nlm.nih.gov/pubmed/36274935
http://dx.doi.org/10.1016/j.isci.2022.105268

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