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Flexibility of functional neuronal assemblies supports human memory

Episodic memories, or consciously accessible memories of unique events, represent a key aspect of human cognition. Evidence from rodent models suggests that the neural representation of these complex memories requires cooperative firing of groups of neurons on short time scales, organized by gamma o...

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Autores principales: Umbach, Gray, Tan, Ryan, Jacobs, Joshua, Pfeiffer, Brad E., Lega, Bradley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579146/
https://www.ncbi.nlm.nih.gov/pubmed/36257934
http://dx.doi.org/10.1038/s41467-022-33587-0
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author Umbach, Gray
Tan, Ryan
Jacobs, Joshua
Pfeiffer, Brad E.
Lega, Bradley
author_facet Umbach, Gray
Tan, Ryan
Jacobs, Joshua
Pfeiffer, Brad E.
Lega, Bradley
author_sort Umbach, Gray
collection PubMed
description Episodic memories, or consciously accessible memories of unique events, represent a key aspect of human cognition. Evidence from rodent models suggests that the neural representation of these complex memories requires cooperative firing of groups of neurons on short time scales, organized by gamma oscillations. These co-firing groups, termed “neuronal assemblies,” represent a fundamental neurophysiological unit supporting memory. Using microelectrode data from neurosurgical patients, we identify neuronal assemblies in the human MTL and show that they exhibit consistent organization in their firing pattern based on gamma phase information. We connect these properties to memory performance across recording sessions. Finally, we describe how human neuronal assemblies flexibly adjust over longer time scales. Our findings provide key evidence linking assemblies to human episodic memory for the first time.
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spelling pubmed-95791462022-10-20 Flexibility of functional neuronal assemblies supports human memory Umbach, Gray Tan, Ryan Jacobs, Joshua Pfeiffer, Brad E. Lega, Bradley Nat Commun Article Episodic memories, or consciously accessible memories of unique events, represent a key aspect of human cognition. Evidence from rodent models suggests that the neural representation of these complex memories requires cooperative firing of groups of neurons on short time scales, organized by gamma oscillations. These co-firing groups, termed “neuronal assemblies,” represent a fundamental neurophysiological unit supporting memory. Using microelectrode data from neurosurgical patients, we identify neuronal assemblies in the human MTL and show that they exhibit consistent organization in their firing pattern based on gamma phase information. We connect these properties to memory performance across recording sessions. Finally, we describe how human neuronal assemblies flexibly adjust over longer time scales. Our findings provide key evidence linking assemblies to human episodic memory for the first time. Nature Publishing Group UK 2022-10-18 /pmc/articles/PMC9579146/ /pubmed/36257934 http://dx.doi.org/10.1038/s41467-022-33587-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Umbach, Gray
Tan, Ryan
Jacobs, Joshua
Pfeiffer, Brad E.
Lega, Bradley
Flexibility of functional neuronal assemblies supports human memory
title Flexibility of functional neuronal assemblies supports human memory
title_full Flexibility of functional neuronal assemblies supports human memory
title_fullStr Flexibility of functional neuronal assemblies supports human memory
title_full_unstemmed Flexibility of functional neuronal assemblies supports human memory
title_short Flexibility of functional neuronal assemblies supports human memory
title_sort flexibility of functional neuronal assemblies supports human memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579146/
https://www.ncbi.nlm.nih.gov/pubmed/36257934
http://dx.doi.org/10.1038/s41467-022-33587-0
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