Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism

The metzincin metalloproteinase PAPP-A plays a key role in the regulation of insulin-like growth factor (IGF) signaling by specific cleavage of inhibitory IGF binding proteins (IGFBPs). Using single-particle cryo-electron microscopy (cryo-EM), we here report the structure of PAPP-A in complex with i...

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Detalles Bibliográficos
Autores principales: Kobberø, Sara Dam, Gajhede, Michael, Mirza, Osman Asghar, Kløverpris, Søren, Kjær, Troels Rønn, Mikkelsen, Jakob Hauge, Boesen, Thomas, Oxvig, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579167/
https://www.ncbi.nlm.nih.gov/pubmed/36257932
http://dx.doi.org/10.1038/s41467-022-33698-8

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