A synthetic transcription platform for programmable gene expression in mammalian cells

Precise, scalable, and sustainable control of genetic and cellular activities in mammalian cells is key to developing precision therapeutics and smart biomanufacturing. Here we create a highly tunable, modular, versatile CRISPR-based synthetic transcription system for the programmable control of gen...

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Detalles Bibliográficos
Autores principales: Chen, William C. W., Gaidukov, Leonid, Lai, Yong, Wu, Ming-Ru, Cao, Jicong, Gutbrod, Michael J., Choi, Gigi C. G., Utomo, Rachel P., Chen, Ying-Chou, Wroblewska, Liliana, Kellis, Manolis, Zhang, Lin, Weiss, Ron, Lu, Timothy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579178/
https://www.ncbi.nlm.nih.gov/pubmed/36257931
http://dx.doi.org/10.1038/s41467-022-33287-9

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