Cargando…

COVID-19 and the Kidney: Recent Advances and Controversies

Kidney involvement is common in coronavirus disease-2019 (COVID-19), and our understanding of the effects of COVID-19 on short- and long-term kidney outcomes has evolved over the course of the pandemic. Initial key questions centered on the spectrum and degree of acute kidney injury (AKI) in patient...

Descripción completa

Detalles Bibliográficos
Autores principales: Menez, Steven, Parikh, Chirag R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579187/
https://www.ncbi.nlm.nih.gov/pubmed/36435682
http://dx.doi.org/10.1016/j.semnephrol.2022.10.005
_version_ 1784812132925177856
author Menez, Steven
Parikh, Chirag R.
author_facet Menez, Steven
Parikh, Chirag R.
author_sort Menez, Steven
collection PubMed
description Kidney involvement is common in coronavirus disease-2019 (COVID-19), and our understanding of the effects of COVID-19 on short- and long-term kidney outcomes has evolved over the course of the pandemic. Initial key questions centered on the spectrum and degree of acute kidney injury (AKI) in patients hospitalized with severe COVID-19. Investigators worldwide have explored the association between COVID-19–associated AKI and short-term outcomes, including inpatient mortality and disease severity. Even as treatments evolved, vaccinations were developed, and newer viral variants arose, subsets of patients were identified as at continued high risk for major adverse kidney outcomes. In this review, we explore key topics of continued relevance including the following: (1) a comparison of COVID-19–associated AKI with AKI developing in other clinical settings; (2) the ongoing controversy over kidney tropism in the setting of COVID-19 and the potential for competitive binding of the severe acute respiratory syndrome coronavirus 2 virus with angiotensin converting enzyme-2 to prevent viral cell entry; and (3) the identification of high-risk patients for adverse outcomes to inform long-term outpatient management. Patients at particularly high risk for adverse kidney outcomes include those with APOL1 high-risk genotype status. Biomarkers of injury, inflammation, tubular health, and repair measured in both the blood and urine may hold prognostic significance.
format Online
Article
Text
id pubmed-9579187
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-95791872022-10-19 COVID-19 and the Kidney: Recent Advances and Controversies Menez, Steven Parikh, Chirag R. Semin Nephrol Article Kidney involvement is common in coronavirus disease-2019 (COVID-19), and our understanding of the effects of COVID-19 on short- and long-term kidney outcomes has evolved over the course of the pandemic. Initial key questions centered on the spectrum and degree of acute kidney injury (AKI) in patients hospitalized with severe COVID-19. Investigators worldwide have explored the association between COVID-19–associated AKI and short-term outcomes, including inpatient mortality and disease severity. Even as treatments evolved, vaccinations were developed, and newer viral variants arose, subsets of patients were identified as at continued high risk for major adverse kidney outcomes. In this review, we explore key topics of continued relevance including the following: (1) a comparison of COVID-19–associated AKI with AKI developing in other clinical settings; (2) the ongoing controversy over kidney tropism in the setting of COVID-19 and the potential for competitive binding of the severe acute respiratory syndrome coronavirus 2 virus with angiotensin converting enzyme-2 to prevent viral cell entry; and (3) the identification of high-risk patients for adverse outcomes to inform long-term outpatient management. Patients at particularly high risk for adverse kidney outcomes include those with APOL1 high-risk genotype status. Biomarkers of injury, inflammation, tubular health, and repair measured in both the blood and urine may hold prognostic significance. Published by Elsevier Inc. 2022-05 2022-10-19 /pmc/articles/PMC9579187/ /pubmed/36435682 http://dx.doi.org/10.1016/j.semnephrol.2022.10.005 Text en © 2022 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Menez, Steven
Parikh, Chirag R.
COVID-19 and the Kidney: Recent Advances and Controversies
title COVID-19 and the Kidney: Recent Advances and Controversies
title_full COVID-19 and the Kidney: Recent Advances and Controversies
title_fullStr COVID-19 and the Kidney: Recent Advances and Controversies
title_full_unstemmed COVID-19 and the Kidney: Recent Advances and Controversies
title_short COVID-19 and the Kidney: Recent Advances and Controversies
title_sort covid-19 and the kidney: recent advances and controversies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579187/
https://www.ncbi.nlm.nih.gov/pubmed/36435682
http://dx.doi.org/10.1016/j.semnephrol.2022.10.005
work_keys_str_mv AT menezsteven covid19andthekidneyrecentadvancesandcontroversies
AT parikhchiragr covid19andthekidneyrecentadvancesandcontroversies