Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)

The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the health...

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Autores principales: Shekhar, Chandra, Nasam, Rajesh, Paipuri, Siva Ramakrishna, Kumar, Prakash, Nayani, Kiranmai, Pabbaraja, Srihari, Mainkar, Prathama S., Chandrasekhar, Srivari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579207/
https://www.ncbi.nlm.nih.gov/pubmed/36276807
http://dx.doi.org/10.1016/j.tchem.2022.100033
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author Shekhar, Chandra
Nasam, Rajesh
Paipuri, Siva Ramakrishna
Kumar, Prakash
Nayani, Kiranmai
Pabbaraja, Srihari
Mainkar, Prathama S.
Chandrasekhar, Srivari
author_facet Shekhar, Chandra
Nasam, Rajesh
Paipuri, Siva Ramakrishna
Kumar, Prakash
Nayani, Kiranmai
Pabbaraja, Srihari
Mainkar, Prathama S.
Chandrasekhar, Srivari
author_sort Shekhar, Chandra
collection PubMed
description The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the healthcare response to combat the ongoing threat by COVID-19. Here, we report an efficient synthesis of nirmatrelvir (PF-07321332), an orally active SARS-CoV-2 main protease inhibitor.
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spelling pubmed-95792072022-10-19 Total synthesis of antiviral drug, nirmatrelvir (PF-07321332) Shekhar, Chandra Nasam, Rajesh Paipuri, Siva Ramakrishna Kumar, Prakash Nayani, Kiranmai Pabbaraja, Srihari Mainkar, Prathama S. Chandrasekhar, Srivari Tetrahedron Chem Article The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the healthcare response to combat the ongoing threat by COVID-19. Here, we report an efficient synthesis of nirmatrelvir (PF-07321332), an orally active SARS-CoV-2 main protease inhibitor. The Authors. Published by Elsevier Ltd. 2022-12 2022-10-19 /pmc/articles/PMC9579207/ /pubmed/36276807 http://dx.doi.org/10.1016/j.tchem.2022.100033 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Shekhar, Chandra
Nasam, Rajesh
Paipuri, Siva Ramakrishna
Kumar, Prakash
Nayani, Kiranmai
Pabbaraja, Srihari
Mainkar, Prathama S.
Chandrasekhar, Srivari
Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title_full Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title_fullStr Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title_full_unstemmed Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title_short Total synthesis of antiviral drug, nirmatrelvir (PF-07321332)
title_sort total synthesis of antiviral drug, nirmatrelvir (pf-07321332)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579207/
https://www.ncbi.nlm.nih.gov/pubmed/36276807
http://dx.doi.org/10.1016/j.tchem.2022.100033
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