The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes

Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule...

Descripción completa

Detalles Bibliográficos
Autores principales: Torii, Tomohiro, Miyasaka, Tomohiro, Misonou, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579343/
https://www.ncbi.nlm.nih.gov/pubmed/36274848
http://dx.doi.org/10.3389/fcell.2022.950682
_version_ 1784812160470220800
author Torii, Tomohiro
Miyasaka, Tomohiro
Misonou, Hiroaki
author_facet Torii, Tomohiro
Miyasaka, Tomohiro
Misonou, Hiroaki
author_sort Torii, Tomohiro
collection PubMed
description Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule and its binding partner Tau might be necessary for oligodendrocyte function based on previous reports.
format Online
Article
Text
id pubmed-9579343
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95793432022-10-20 The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes Torii, Tomohiro Miyasaka, Tomohiro Misonou, Hiroaki Front Cell Dev Biol Cell and Developmental Biology Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of tau are dramatical changed in hypomyelination model rat and in demyelination region of stroke model mice. The review demonstrate microtubule and its binding partner Tau might be necessary for oligodendrocyte function based on previous reports. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579343/ /pubmed/36274848 http://dx.doi.org/10.3389/fcell.2022.950682 Text en Copyright © 2022 Torii, Miyasaka and Misonou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Torii, Tomohiro
Miyasaka, Tomohiro
Misonou, Hiroaki
The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title_full The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title_fullStr The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title_full_unstemmed The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title_short The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
title_sort organization of microtubules and tau in oligodendrocytes: tau pathology in damaged oligodendrocytes
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579343/
https://www.ncbi.nlm.nih.gov/pubmed/36274848
http://dx.doi.org/10.3389/fcell.2022.950682
work_keys_str_mv AT toriitomohiro theorganizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes
AT miyasakatomohiro theorganizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes
AT misonouhiroaki theorganizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes
AT toriitomohiro organizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes
AT miyasakatomohiro organizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes
AT misonouhiroaki organizationofmicrotubulesandtauinoligodendrocytestaupathologyindamagedoligodendrocytes

Ejemplares similares