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A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction

Progressive infarction (PI) is common in small subcortical infarction and may lead to a poor outcome. The purpose of our study is to identify neuroimaging predictors for PI. From April 2017 to December 2020, we enrolled 86 patients with an anterior circulation subcortical infarction within 48 h afte...

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Autores principales: Lin, Jing, Mao, Xiaocheng, Liao, Yunfang, Luo, Si, Huang, Qin, Song, Ziwei, Li, Shumeng, Li, Chengjin, Qiu, Yuexin, Wu, Yuhang, Zhu, Min, Li, Xiaobing, Yu, Qiulong, Hong, Daojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579366/
https://www.ncbi.nlm.nih.gov/pubmed/36277920
http://dx.doi.org/10.3389/fneur.2022.926187
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author Lin, Jing
Mao, Xiaocheng
Liao, Yunfang
Luo, Si
Huang, Qin
Song, Ziwei
Li, Shumeng
Li, Chengjin
Qiu, Yuexin
Wu, Yuhang
Zhu, Min
Li, Xiaobing
Yu, Qiulong
Hong, Daojun
author_facet Lin, Jing
Mao, Xiaocheng
Liao, Yunfang
Luo, Si
Huang, Qin
Song, Ziwei
Li, Shumeng
Li, Chengjin
Qiu, Yuexin
Wu, Yuhang
Zhu, Min
Li, Xiaobing
Yu, Qiulong
Hong, Daojun
author_sort Lin, Jing
collection PubMed
description Progressive infarction (PI) is common in small subcortical infarction and may lead to a poor outcome. The purpose of our study is to identify neuroimaging predictors for PI. From April 2017 to December 2020, we enrolled 86 patients with an anterior circulation subcortical infarction within 48 h after onset. Progressive infarction was defined by an increase of ≥ one point in motor power or ≥ two points in the total National Institute of Health Stroke Scale score within 7 days after admission and further confirmed by diffusion-weighted imaging (DWI). To identify predictors, demographic characteristics, clinical information, laboratory date, and neuroimaging characteristics were evaluated. The infarct size and infarct slice number were measured by DWI. We found that thirty-one patients (36%) had PI. In a univariate analysis, the patients with PI had higher levels of triglyceride, lower levels of blood urea nitrogen and prothrombin time, and a higher frequency of infarct slice number ≥ three compared to the patients without PI. After logistic regression stepwise adjustment for all considered relevant confounders, infarct slice number ≥ three slices proved to be independently associated with PI (OR = 4.781, 95% CI 1.677–13.627; OR = 4.867, 95% CI 1.6–14.864; OR = 3.584, 95% CI 1.034–12.420). Our study showed that a lesion extending ≥ three slices on DWI is an independent predictor for progressive infarction in patients with anterior circulation small subcortical infarction.
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spelling pubmed-95793662022-10-20 A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction Lin, Jing Mao, Xiaocheng Liao, Yunfang Luo, Si Huang, Qin Song, Ziwei Li, Shumeng Li, Chengjin Qiu, Yuexin Wu, Yuhang Zhu, Min Li, Xiaobing Yu, Qiulong Hong, Daojun Front Neurol Neurology Progressive infarction (PI) is common in small subcortical infarction and may lead to a poor outcome. The purpose of our study is to identify neuroimaging predictors for PI. From April 2017 to December 2020, we enrolled 86 patients with an anterior circulation subcortical infarction within 48 h after onset. Progressive infarction was defined by an increase of ≥ one point in motor power or ≥ two points in the total National Institute of Health Stroke Scale score within 7 days after admission and further confirmed by diffusion-weighted imaging (DWI). To identify predictors, demographic characteristics, clinical information, laboratory date, and neuroimaging characteristics were evaluated. The infarct size and infarct slice number were measured by DWI. We found that thirty-one patients (36%) had PI. In a univariate analysis, the patients with PI had higher levels of triglyceride, lower levels of blood urea nitrogen and prothrombin time, and a higher frequency of infarct slice number ≥ three compared to the patients without PI. After logistic regression stepwise adjustment for all considered relevant confounders, infarct slice number ≥ three slices proved to be independently associated with PI (OR = 4.781, 95% CI 1.677–13.627; OR = 4.867, 95% CI 1.6–14.864; OR = 3.584, 95% CI 1.034–12.420). Our study showed that a lesion extending ≥ three slices on DWI is an independent predictor for progressive infarction in patients with anterior circulation small subcortical infarction. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579366/ /pubmed/36277920 http://dx.doi.org/10.3389/fneur.2022.926187 Text en Copyright © 2022 Lin, Mao, Liao, Luo, Huang, Song, Li, Li, Qiu, Wu, Zhu, Li, Yu and Hong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Lin, Jing
Mao, Xiaocheng
Liao, Yunfang
Luo, Si
Huang, Qin
Song, Ziwei
Li, Shumeng
Li, Chengjin
Qiu, Yuexin
Wu, Yuhang
Zhu, Min
Li, Xiaobing
Yu, Qiulong
Hong, Daojun
A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title_full A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title_fullStr A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title_full_unstemmed A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title_short A lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
title_sort lesion extending three or more slices as a predictor of progressive infarction in anterior circulation small subcortical infarction
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579366/
https://www.ncbi.nlm.nih.gov/pubmed/36277920
http://dx.doi.org/10.3389/fneur.2022.926187
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