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Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury
Spinal cord injury (SCI) is a devastating central nervous system disease, caused by physical traumas. With the characteristic of high disability rate, catastrophic dysfunction, and enormous burden on the patient’s family, SCI has become a tough neurological problem without efficient treatments. Cont...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579378/ https://www.ncbi.nlm.nih.gov/pubmed/36278149 http://dx.doi.org/10.3389/fphar.2022.976757 |
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author | Huang, Zhihua Wang, Jingyi Li, Chun Zheng, Weihong He, Junyuan Wu, Ziguang Tang, Jianbang |
author_facet | Huang, Zhihua Wang, Jingyi Li, Chun Zheng, Weihong He, Junyuan Wu, Ziguang Tang, Jianbang |
author_sort | Huang, Zhihua |
collection | PubMed |
description | Spinal cord injury (SCI) is a devastating central nervous system disease, caused by physical traumas. With the characteristic of high disability rate, catastrophic dysfunction, and enormous burden on the patient’s family, SCI has become a tough neurological problem without efficient treatments. Contemporarily, the pathophysiology of SCI comprises complicated and underlying mechanisms, in which oxidative stress (OS) may play a critical role in contributing to a cascade of secondary injuries. OS substantively leads to ion imbalance, lipid peroxidation, inflammatory cell infiltration, mitochondrial disorder, and neuronal dysfunction. Hence, seeking the therapeutic intervention of alleviating OS and appropriate antioxidants is an essential clinical strategy. Previous studies have reported that traditional Chinese medicine (TCM) has antioxidant, anti-inflammatory, antiapoptotic and neuroprotective effects on alleviating SCI. Notably, the antioxidant effects of some metabolites and compounds of TCM have obtained numerous verifications, suggesting a potential therapeutic strategy for SCI. This review aims at investigating the mechanisms of OS in SCI and highlighting some TCM with antioxidant capacity used in the treatment of SCI. |
format | Online Article Text |
id | pubmed-9579378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95793782022-10-20 Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury Huang, Zhihua Wang, Jingyi Li, Chun Zheng, Weihong He, Junyuan Wu, Ziguang Tang, Jianbang Front Pharmacol Pharmacology Spinal cord injury (SCI) is a devastating central nervous system disease, caused by physical traumas. With the characteristic of high disability rate, catastrophic dysfunction, and enormous burden on the patient’s family, SCI has become a tough neurological problem without efficient treatments. Contemporarily, the pathophysiology of SCI comprises complicated and underlying mechanisms, in which oxidative stress (OS) may play a critical role in contributing to a cascade of secondary injuries. OS substantively leads to ion imbalance, lipid peroxidation, inflammatory cell infiltration, mitochondrial disorder, and neuronal dysfunction. Hence, seeking the therapeutic intervention of alleviating OS and appropriate antioxidants is an essential clinical strategy. Previous studies have reported that traditional Chinese medicine (TCM) has antioxidant, anti-inflammatory, antiapoptotic and neuroprotective effects on alleviating SCI. Notably, the antioxidant effects of some metabolites and compounds of TCM have obtained numerous verifications, suggesting a potential therapeutic strategy for SCI. This review aims at investigating the mechanisms of OS in SCI and highlighting some TCM with antioxidant capacity used in the treatment of SCI. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579378/ /pubmed/36278149 http://dx.doi.org/10.3389/fphar.2022.976757 Text en Copyright © 2022 Huang, Wang, Li, Zheng, He, Wu and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Huang, Zhihua Wang, Jingyi Li, Chun Zheng, Weihong He, Junyuan Wu, Ziguang Tang, Jianbang Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title | Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title_full | Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title_fullStr | Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title_full_unstemmed | Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title_short | Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury |
title_sort | application of natural antioxidants from traditional chinese medicine in the treatment of spinal cord injury |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579378/ https://www.ncbi.nlm.nih.gov/pubmed/36278149 http://dx.doi.org/10.3389/fphar.2022.976757 |
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