Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites

Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non...

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Detalles Bibliográficos
Autores principales: Petrova, Yoana D., Mahenthiralingam, Eshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579380/
https://www.ncbi.nlm.nih.gov/pubmed/36277081
http://dx.doi.org/10.1016/j.tcsw.2022.100081
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author Petrova, Yoana D.
Mahenthiralingam, Eshwar
author_facet Petrova, Yoana D.
Mahenthiralingam, Eshwar
author_sort Petrova, Yoana D.
collection PubMed
description Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non-ribosomal peptides and hybrid polyketide non-ribosomal peptides. We highlight examples of Burkholderia metabolites, overviewing their biosynthesis, bioactivity, mechanisms of action and secretion.
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spelling pubmed-95793802022-10-20 Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites Petrova, Yoana D. Mahenthiralingam, Eshwar Cell Surf Article Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non-ribosomal peptides and hybrid polyketide non-ribosomal peptides. We highlight examples of Burkholderia metabolites, overviewing their biosynthesis, bioactivity, mechanisms of action and secretion. Elsevier 2022-10-13 /pmc/articles/PMC9579380/ /pubmed/36277081 http://dx.doi.org/10.1016/j.tcsw.2022.100081 Text en Crown Copyright © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petrova, Yoana D.
Mahenthiralingam, Eshwar
Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title_full Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title_fullStr Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title_full_unstemmed Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title_short Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites
title_sort discovery, mode of action and secretion of burkholderia sensu lato key antimicrobial specialised metabolites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579380/
https://www.ncbi.nlm.nih.gov/pubmed/36277081
http://dx.doi.org/10.1016/j.tcsw.2022.100081
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