SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

Intrathecal administration enables central nervous system delivery of drugs that do not bypass the blood-brain barrier. Systemic administration of hypertonic saline (HTS) enhances delivery of intrathecal therapeutics into the neuropil, but its effect on solute clearance from the brain remains unknow...

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Detalles Bibliográficos
Autores principales: Lilius, Tuomas O., Rosenholm, Marko, Klinger, Laura, Mortensen, Kristian Nygaard, Sigurdsson, Björn, Mogensen, Frida Lind-Holm, Hauglund, Natalie L., Nielsen, Malthe Skytte Nordentoft, Rantamäki, Tomi, Nedergaard, Maiken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579504/
https://www.ncbi.nlm.nih.gov/pubmed/36274948
http://dx.doi.org/10.1016/j.isci.2022.105250

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