Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3

The clinical correlation between adiponectin (APN) signal and hypertrophic scar (HS) remains unclear. Here, we found significantly reduced expression of APN receptors (AdipoR1/2) in HS tissues and derived fibroblasts (HFs), suggesting that HS formation may be associated with APN/AdipoR1/2 decline. R...

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Detalles Bibliográficos
Autores principales: Zhang, Jian, Li, Yan, Liu, Jiaqi, Han, Fu, Shi, Jihong, Wu, Gaofeng, Wang, Kejia, Shen, Kuo, Zhao, Ming, Gao, Xiaowen, Tian, Chenyang, Wang, Yunchuan, Tao, Ke, Hu, Dahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579505/
https://www.ncbi.nlm.nih.gov/pubmed/36274941
http://dx.doi.org/10.1016/j.isci.2022.105236

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