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Functional Imaging in Olfactory Disorders
PURPOSE OF REVIEW: The aim was to synthesize key findings regarding the use of functional MRI (fMRI) to assess olfactory dysfunction (OD), and thus, to evaluate whether fMRI could be a reliable clinical diagnostic tool. RECENT FINDINGS: In response to olfactory stimulation, patients with quantitativ...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579609/ https://www.ncbi.nlm.nih.gov/pubmed/36276577 http://dx.doi.org/10.1007/s40136-022-00433-2 |
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author | Van Regemorter, V. Rombaux, Ph. Dricot, L. Kupers, R. Grégoire, A. Hox, V. Huart, C. |
author_facet | Van Regemorter, V. Rombaux, Ph. Dricot, L. Kupers, R. Grégoire, A. Hox, V. Huart, C. |
author_sort | Van Regemorter, V. |
collection | PubMed |
description | PURPOSE OF REVIEW: The aim was to synthesize key findings regarding the use of functional MRI (fMRI) to assess olfactory dysfunction (OD), and thus, to evaluate whether fMRI could be a reliable clinical diagnostic tool. RECENT FINDINGS: In response to olfactory stimulation, patients with quantitative OD display reduced activation in olfactory-related brain regions but also stronger activation in non-olfactory brain areas. Parosmic patients also seem to show both weaker and higher brain signals. As to trigeminal chemosensory system, fMRI suggests that central processing may be declined in patients with OD. Functional connectivity studies report a possible correlation between altered neuronal connections within brain networks and olfactory performances. SUMMARY: fMRI emerges as a valuable and promising objective method in OD evaluation. Yet, its high inter-individual variability still precludes its routine clinical use for diagnostic purpose. Future research should focus on optimizing stimulation paradigms and analysis methods. |
format | Online Article Text |
id | pubmed-9579609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-95796092022-10-19 Functional Imaging in Olfactory Disorders Van Regemorter, V. Rombaux, Ph. Dricot, L. Kupers, R. Grégoire, A. Hox, V. Huart, C. Curr Otorhinolaryngol Rep RHINOLOGY: Taste and Smell Disorders (C Philpott, Section Editor) PURPOSE OF REVIEW: The aim was to synthesize key findings regarding the use of functional MRI (fMRI) to assess olfactory dysfunction (OD), and thus, to evaluate whether fMRI could be a reliable clinical diagnostic tool. RECENT FINDINGS: In response to olfactory stimulation, patients with quantitative OD display reduced activation in olfactory-related brain regions but also stronger activation in non-olfactory brain areas. Parosmic patients also seem to show both weaker and higher brain signals. As to trigeminal chemosensory system, fMRI suggests that central processing may be declined in patients with OD. Functional connectivity studies report a possible correlation between altered neuronal connections within brain networks and olfactory performances. SUMMARY: fMRI emerges as a valuable and promising objective method in OD evaluation. Yet, its high inter-individual variability still precludes its routine clinical use for diagnostic purpose. Future research should focus on optimizing stimulation paradigms and analysis methods. Springer US 2022-10-19 2022 /pmc/articles/PMC9579609/ /pubmed/36276577 http://dx.doi.org/10.1007/s40136-022-00433-2 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | RHINOLOGY: Taste and Smell Disorders (C Philpott, Section Editor) Van Regemorter, V. Rombaux, Ph. Dricot, L. Kupers, R. Grégoire, A. Hox, V. Huart, C. Functional Imaging in Olfactory Disorders |
title | Functional Imaging in Olfactory Disorders |
title_full | Functional Imaging in Olfactory Disorders |
title_fullStr | Functional Imaging in Olfactory Disorders |
title_full_unstemmed | Functional Imaging in Olfactory Disorders |
title_short | Functional Imaging in Olfactory Disorders |
title_sort | functional imaging in olfactory disorders |
topic | RHINOLOGY: Taste and Smell Disorders (C Philpott, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579609/ https://www.ncbi.nlm.nih.gov/pubmed/36276577 http://dx.doi.org/10.1007/s40136-022-00433-2 |
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