FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems with opiate withdrawal. Preclinical and preliminary clinical evidence sug...

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Detalles Bibliográficos
Autores principales: Paterson, L. M., Barker, D., Cro, S., Mozgunov, P., Phillips, R., Smith, C., Nahar, L., Paterson, S., Lingford-Hughes, A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579625/
https://www.ncbi.nlm.nih.gov/pubmed/36258248
http://dx.doi.org/10.1186/s13063-022-06821-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579625/
https://www.ncbi.nlm.nih.gov/pubmed/36258248
http://dx.doi.org/10.1186/s13063-022-06821-9

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