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The dual role of CD6 as a therapeutic target in cancer and autoimmune disease

Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer...

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Autores principales: Gurrea-Rubio, Mikel, Fox, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579686/
https://www.ncbi.nlm.nih.gov/pubmed/36275816
http://dx.doi.org/10.3389/fmed.2022.1026521
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author Gurrea-Rubio, Mikel
Fox, David A.
author_facet Gurrea-Rubio, Mikel
Fox, David A.
author_sort Gurrea-Rubio, Mikel
collection PubMed
description Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer treatments, especially checkpoint inhibitor therapies, can induce severe autoimmune syndromes. There is recent evidence that autoimmunity and cancer share molecular targets and pathways that may be dysregulated in both types of diseases. Therefore, there has been an increased focus on understanding these biological pathways that link cancer and its treatment with the appearance of autoimmunity. In this review, we hope to consolidate our understanding of current and emerging molecular targets used to treat both cancer and autoimmunity, with a special focus on Cluster of Differentiation (CD) 6.
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spelling pubmed-95796862022-10-20 The dual role of CD6 as a therapeutic target in cancer and autoimmune disease Gurrea-Rubio, Mikel Fox, David A. Front Med (Lausanne) Medicine Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer treatments, especially checkpoint inhibitor therapies, can induce severe autoimmune syndromes. There is recent evidence that autoimmunity and cancer share molecular targets and pathways that may be dysregulated in both types of diseases. Therefore, there has been an increased focus on understanding these biological pathways that link cancer and its treatment with the appearance of autoimmunity. In this review, we hope to consolidate our understanding of current and emerging molecular targets used to treat both cancer and autoimmunity, with a special focus on Cluster of Differentiation (CD) 6. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579686/ /pubmed/36275816 http://dx.doi.org/10.3389/fmed.2022.1026521 Text en Copyright © 2022 Gurrea-Rubio and Fox. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Gurrea-Rubio, Mikel
Fox, David A.
The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title_full The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title_fullStr The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title_full_unstemmed The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title_short The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
title_sort dual role of cd6 as a therapeutic target in cancer and autoimmune disease
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579686/
https://www.ncbi.nlm.nih.gov/pubmed/36275816
http://dx.doi.org/10.3389/fmed.2022.1026521
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