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The dual role of CD6 as a therapeutic target in cancer and autoimmune disease
Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579686/ https://www.ncbi.nlm.nih.gov/pubmed/36275816 http://dx.doi.org/10.3389/fmed.2022.1026521 |
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author | Gurrea-Rubio, Mikel Fox, David A. |
author_facet | Gurrea-Rubio, Mikel Fox, David A. |
author_sort | Gurrea-Rubio, Mikel |
collection | PubMed |
description | Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer treatments, especially checkpoint inhibitor therapies, can induce severe autoimmune syndromes. There is recent evidence that autoimmunity and cancer share molecular targets and pathways that may be dysregulated in both types of diseases. Therefore, there has been an increased focus on understanding these biological pathways that link cancer and its treatment with the appearance of autoimmunity. In this review, we hope to consolidate our understanding of current and emerging molecular targets used to treat both cancer and autoimmunity, with a special focus on Cluster of Differentiation (CD) 6. |
format | Online Article Text |
id | pubmed-9579686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95796862022-10-20 The dual role of CD6 as a therapeutic target in cancer and autoimmune disease Gurrea-Rubio, Mikel Fox, David A. Front Med (Lausanne) Medicine Autoimmune disease involves loss of tolerance to self-antigen, while progression of cancer reflects insufficient recognition and response of the immune system to malignant cells. Patients with immune compromised conditions tend to be more susceptible to cancer development. On the other hand, cancer treatments, especially checkpoint inhibitor therapies, can induce severe autoimmune syndromes. There is recent evidence that autoimmunity and cancer share molecular targets and pathways that may be dysregulated in both types of diseases. Therefore, there has been an increased focus on understanding these biological pathways that link cancer and its treatment with the appearance of autoimmunity. In this review, we hope to consolidate our understanding of current and emerging molecular targets used to treat both cancer and autoimmunity, with a special focus on Cluster of Differentiation (CD) 6. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579686/ /pubmed/36275816 http://dx.doi.org/10.3389/fmed.2022.1026521 Text en Copyright © 2022 Gurrea-Rubio and Fox. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Gurrea-Rubio, Mikel Fox, David A. The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title | The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title_full | The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title_fullStr | The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title_full_unstemmed | The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title_short | The dual role of CD6 as a therapeutic target in cancer and autoimmune disease |
title_sort | dual role of cd6 as a therapeutic target in cancer and autoimmune disease |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579686/ https://www.ncbi.nlm.nih.gov/pubmed/36275816 http://dx.doi.org/10.3389/fmed.2022.1026521 |
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