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Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579688/ https://www.ncbi.nlm.nih.gov/pubmed/36277776 http://dx.doi.org/10.3389/fcvm.2022.959815 |
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author | Devarajan, Asokan Wang, Ke Shannon, Kassandra Su, Yujuan Verheyden, Jamie Sun, Xin Vaseghi, Marmar |
author_facet | Devarajan, Asokan Wang, Ke Shannon, Kassandra Su, Yujuan Verheyden, Jamie Sun, Xin Vaseghi, Marmar |
author_sort | Devarajan, Asokan |
collection | PubMed |
description | Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of sensory neural pathways present in the autonomic ganglia. Using neurotracer approaches with appropriate negative control experiments in a mouse model, presence of cardiorespiratory neurons in the vagal (nodose) ganglia are demonstrated. Furthermore, we found that convergent neurons represent nearly 50% of all cardiac neurons and approximately 35% of all respiratory neurons. The current findings demonstrate a pre-existing neuronal substrate linking cardiorespiratory neurotransmission in the vagal ganglia, and a potentially important link for cardiopulmonary cross-sensitization, which may play an important role in the observed manifestations of cardiopulmonary diseases. |
format | Online Article Text |
id | pubmed-9579688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95796882022-10-20 Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia Devarajan, Asokan Wang, Ke Shannon, Kassandra Su, Yujuan Verheyden, Jamie Sun, Xin Vaseghi, Marmar Front Cardiovasc Med Cardiovascular Medicine Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of sensory neural pathways present in the autonomic ganglia. Using neurotracer approaches with appropriate negative control experiments in a mouse model, presence of cardiorespiratory neurons in the vagal (nodose) ganglia are demonstrated. Furthermore, we found that convergent neurons represent nearly 50% of all cardiac neurons and approximately 35% of all respiratory neurons. The current findings demonstrate a pre-existing neuronal substrate linking cardiorespiratory neurotransmission in the vagal ganglia, and a potentially important link for cardiopulmonary cross-sensitization, which may play an important role in the observed manifestations of cardiopulmonary diseases. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579688/ /pubmed/36277776 http://dx.doi.org/10.3389/fcvm.2022.959815 Text en Copyright © 2022 Devarajan, Wang, Shannon, Su, Verheyden, Sun and Vaseghi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Devarajan, Asokan Wang, Ke Shannon, Kassandra Su, Yujuan Verheyden, Jamie Sun, Xin Vaseghi, Marmar Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title | Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title_full | Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title_fullStr | Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title_full_unstemmed | Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title_short | Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
title_sort | convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579688/ https://www.ncbi.nlm.nih.gov/pubmed/36277776 http://dx.doi.org/10.3389/fcvm.2022.959815 |
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