Cargando…

Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia

Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Devarajan, Asokan, Wang, Ke, Shannon, Kassandra, Su, Yujuan, Verheyden, Jamie, Sun, Xin, Vaseghi, Marmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579688/
https://www.ncbi.nlm.nih.gov/pubmed/36277776
http://dx.doi.org/10.3389/fcvm.2022.959815
_version_ 1784812236874711040
author Devarajan, Asokan
Wang, Ke
Shannon, Kassandra
Su, Yujuan
Verheyden, Jamie
Sun, Xin
Vaseghi, Marmar
author_facet Devarajan, Asokan
Wang, Ke
Shannon, Kassandra
Su, Yujuan
Verheyden, Jamie
Sun, Xin
Vaseghi, Marmar
author_sort Devarajan, Asokan
collection PubMed
description Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of sensory neural pathways present in the autonomic ganglia. Using neurotracer approaches with appropriate negative control experiments in a mouse model, presence of cardiorespiratory neurons in the vagal (nodose) ganglia are demonstrated. Furthermore, we found that convergent neurons represent nearly 50% of all cardiac neurons and approximately 35% of all respiratory neurons. The current findings demonstrate a pre-existing neuronal substrate linking cardiorespiratory neurotransmission in the vagal ganglia, and a potentially important link for cardiopulmonary cross-sensitization, which may play an important role in the observed manifestations of cardiopulmonary diseases.
format Online
Article
Text
id pubmed-9579688
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95796882022-10-20 Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia Devarajan, Asokan Wang, Ke Shannon, Kassandra Su, Yujuan Verheyden, Jamie Sun, Xin Vaseghi, Marmar Front Cardiovasc Med Cardiovascular Medicine Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal “cross-talk” between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of sensory neural pathways present in the autonomic ganglia. Using neurotracer approaches with appropriate negative control experiments in a mouse model, presence of cardiorespiratory neurons in the vagal (nodose) ganglia are demonstrated. Furthermore, we found that convergent neurons represent nearly 50% of all cardiac neurons and approximately 35% of all respiratory neurons. The current findings demonstrate a pre-existing neuronal substrate linking cardiorespiratory neurotransmission in the vagal ganglia, and a potentially important link for cardiopulmonary cross-sensitization, which may play an important role in the observed manifestations of cardiopulmonary diseases. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9579688/ /pubmed/36277776 http://dx.doi.org/10.3389/fcvm.2022.959815 Text en Copyright © 2022 Devarajan, Wang, Shannon, Su, Verheyden, Sun and Vaseghi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Devarajan, Asokan
Wang, Ke
Shannon, Kassandra
Su, Yujuan
Verheyden, Jamie
Sun, Xin
Vaseghi, Marmar
Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title_full Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title_fullStr Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title_full_unstemmed Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title_short Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
title_sort convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579688/
https://www.ncbi.nlm.nih.gov/pubmed/36277776
http://dx.doi.org/10.3389/fcvm.2022.959815
work_keys_str_mv AT devarajanasokan convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT wangke convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT shannonkassandra convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT suyujuan convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT verheydenjamie convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT sunxin convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia
AT vaseghimarmar convergentcardiorespiratoryneuronsrepresentasignificantportionofcardiacandrespiratoryneuronsinthevagalganglia