Non-coding antisense transcripts: fine regulation of gene expression in cancer

Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described a...

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Autores principales: Santos, Francisco, Capela, Ana Maria, Mateus, Francisca, Nóbrega-Pereira, Sandrina, Bernardes de Jesus, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579725/
https://www.ncbi.nlm.nih.gov/pubmed/36284703
http://dx.doi.org/10.1016/j.csbj.2022.10.009
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author Santos, Francisco
Capela, Ana Maria
Mateus, Francisca
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author_facet Santos, Francisco
Capela, Ana Maria
Mateus, Francisca
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author_sort Santos, Francisco
collection PubMed
description Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another layer of potential targets in disease. Here, we focus on the interesting and unique role of non-coding NATs in cancer, paying particular attention to those acting as miRNA sponges.
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spelling pubmed-95797252022-10-24 Non-coding antisense transcripts: fine regulation of gene expression in cancer Santos, Francisco Capela, Ana Maria Mateus, Francisca Nóbrega-Pereira, Sandrina Bernardes de Jesus, Bruno Comput Struct Biotechnol J Mini Review Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another layer of potential targets in disease. Here, we focus on the interesting and unique role of non-coding NATs in cancer, paying particular attention to those acting as miRNA sponges. Research Network of Computational and Structural Biotechnology 2022-10-10 /pmc/articles/PMC9579725/ /pubmed/36284703 http://dx.doi.org/10.1016/j.csbj.2022.10.009 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini Review
Santos, Francisco
Capela, Ana Maria
Mateus, Francisca
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
Non-coding antisense transcripts: fine regulation of gene expression in cancer
title Non-coding antisense transcripts: fine regulation of gene expression in cancer
title_full Non-coding antisense transcripts: fine regulation of gene expression in cancer
title_fullStr Non-coding antisense transcripts: fine regulation of gene expression in cancer
title_full_unstemmed Non-coding antisense transcripts: fine regulation of gene expression in cancer
title_short Non-coding antisense transcripts: fine regulation of gene expression in cancer
title_sort non-coding antisense transcripts: fine regulation of gene expression in cancer
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579725/
https://www.ncbi.nlm.nih.gov/pubmed/36284703
http://dx.doi.org/10.1016/j.csbj.2022.10.009
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