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Kaempferol: A potential agent in the prevention of colorectal cancer
Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579739/ https://www.ncbi.nlm.nih.gov/pubmed/36259115 http://dx.doi.org/10.14814/phy2.15488 |
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author | Nejabati, Hamid Reza Roshangar, Leila |
author_facet | Nejabati, Hamid Reza Roshangar, Leila |
author_sort | Nejabati, Hamid Reza |
collection | PubMed |
description | Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC. |
format | Online Article Text |
id | pubmed-9579739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95797392022-10-19 Kaempferol: A potential agent in the prevention of colorectal cancer Nejabati, Hamid Reza Roshangar, Leila Physiol Rep Reviews Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC. John Wiley and Sons Inc. 2022-10-18 /pmc/articles/PMC9579739/ /pubmed/36259115 http://dx.doi.org/10.14814/phy2.15488 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Nejabati, Hamid Reza Roshangar, Leila Kaempferol: A potential agent in the prevention of colorectal cancer |
title | Kaempferol: A potential agent in the prevention of colorectal cancer |
title_full | Kaempferol: A potential agent in the prevention of colorectal cancer |
title_fullStr | Kaempferol: A potential agent in the prevention of colorectal cancer |
title_full_unstemmed | Kaempferol: A potential agent in the prevention of colorectal cancer |
title_short | Kaempferol: A potential agent in the prevention of colorectal cancer |
title_sort | kaempferol: a potential agent in the prevention of colorectal cancer |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579739/ https://www.ncbi.nlm.nih.gov/pubmed/36259115 http://dx.doi.org/10.14814/phy2.15488 |
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