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Kaempferol: A potential agent in the prevention of colorectal cancer

Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo...

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Detalles Bibliográficos
Autores principales: Nejabati, Hamid Reza, Roshangar, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579739/
https://www.ncbi.nlm.nih.gov/pubmed/36259115
http://dx.doi.org/10.14814/phy2.15488
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author Nejabati, Hamid Reza
Roshangar, Leila
author_facet Nejabati, Hamid Reza
Roshangar, Leila
author_sort Nejabati, Hamid Reza
collection PubMed
description Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC.
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spelling pubmed-95797392022-10-19 Kaempferol: A potential agent in the prevention of colorectal cancer Nejabati, Hamid Reza Roshangar, Leila Physiol Rep Reviews Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo‐ and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase‐1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non‐cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC. John Wiley and Sons Inc. 2022-10-18 /pmc/articles/PMC9579739/ /pubmed/36259115 http://dx.doi.org/10.14814/phy2.15488 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Nejabati, Hamid Reza
Roshangar, Leila
Kaempferol: A potential agent in the prevention of colorectal cancer
title Kaempferol: A potential agent in the prevention of colorectal cancer
title_full Kaempferol: A potential agent in the prevention of colorectal cancer
title_fullStr Kaempferol: A potential agent in the prevention of colorectal cancer
title_full_unstemmed Kaempferol: A potential agent in the prevention of colorectal cancer
title_short Kaempferol: A potential agent in the prevention of colorectal cancer
title_sort kaempferol: a potential agent in the prevention of colorectal cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579739/
https://www.ncbi.nlm.nih.gov/pubmed/36259115
http://dx.doi.org/10.14814/phy2.15488
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