The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition

Long-interspersed element 1 (LINE-1) is an autonomous non-LTR retrotransposon. Its replication can cause mutation and rearrangement of host genomic DNA, which may result in serious genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we...

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Autores principales: Zhang, Zixiong, Zhang, Ning, Guo, Saisai, Liu, Qian, Wang, Shujie, Zhang, Ao, Yi, Dongrong, Zhao, Jianyuan, Li, Quanjie, Wang, Jing, Zhang, Yongxin, Ma, Ling, Ding, Jiwei, Cen, Shan, Li, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580041/
https://www.ncbi.nlm.nih.gov/pubmed/36274734
http://dx.doi.org/10.3389/fmicb.2022.891852
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author Zhang, Zixiong
Zhang, Ning
Guo, Saisai
Liu, Qian
Wang, Shujie
Zhang, Ao
Yi, Dongrong
Zhao, Jianyuan
Li, Quanjie
Wang, Jing
Zhang, Yongxin
Ma, Ling
Ding, Jiwei
Cen, Shan
Li, Xiaoyu
author_facet Zhang, Zixiong
Zhang, Ning
Guo, Saisai
Liu, Qian
Wang, Shujie
Zhang, Ao
Yi, Dongrong
Zhao, Jianyuan
Li, Quanjie
Wang, Jing
Zhang, Yongxin
Ma, Ling
Ding, Jiwei
Cen, Shan
Li, Xiaoyu
author_sort Zhang, Zixiong
collection PubMed
description Long-interspersed element 1 (LINE-1) is an autonomous non-LTR retrotransposon. Its replication can cause mutation and rearrangement of host genomic DNA, which may result in serious genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we reported that CCHC-type zinc-finger protein ZCCHC3 can repress LINE-1 retrotransposition, and this activity is closely related to its zinc-finger domain. Further studies show that ZCCHC3 can post-transcriptionally diminish the LINE-1 RNA level. The association of ZCCHC3 with both LINE-1 RNA and ORF1 suggests that ZCCHC3 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstrate collectively that ZCCHC3 contributes to the cellular control of LINE-1 replication.
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spelling pubmed-95800412022-10-20 The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition Zhang, Zixiong Zhang, Ning Guo, Saisai Liu, Qian Wang, Shujie Zhang, Ao Yi, Dongrong Zhao, Jianyuan Li, Quanjie Wang, Jing Zhang, Yongxin Ma, Ling Ding, Jiwei Cen, Shan Li, Xiaoyu Front Microbiol Microbiology Long-interspersed element 1 (LINE-1) is an autonomous non-LTR retrotransposon. Its replication can cause mutation and rearrangement of host genomic DNA, which may result in serious genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we reported that CCHC-type zinc-finger protein ZCCHC3 can repress LINE-1 retrotransposition, and this activity is closely related to its zinc-finger domain. Further studies show that ZCCHC3 can post-transcriptionally diminish the LINE-1 RNA level. The association of ZCCHC3 with both LINE-1 RNA and ORF1 suggests that ZCCHC3 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstrate collectively that ZCCHC3 contributes to the cellular control of LINE-1 replication. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9580041/ /pubmed/36274734 http://dx.doi.org/10.3389/fmicb.2022.891852 Text en Copyright © 2022 Zhang, Zhang, Guo, Liu, Wang, Zhang, Yi, Zhao, Li, Wang, Zhang, Ma, Ding, Cen and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhang, Zixiong
Zhang, Ning
Guo, Saisai
Liu, Qian
Wang, Shujie
Zhang, Ao
Yi, Dongrong
Zhao, Jianyuan
Li, Quanjie
Wang, Jing
Zhang, Yongxin
Ma, Ling
Ding, Jiwei
Cen, Shan
Li, Xiaoyu
The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title_full The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title_fullStr The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title_full_unstemmed The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title_short The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
title_sort zinc-finger protein zcchc3 inhibits line-1 retrotransposition
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580041/
https://www.ncbi.nlm.nih.gov/pubmed/36274734
http://dx.doi.org/10.3389/fmicb.2022.891852
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