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Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions
This review summarizes the current literature on the adverse cardiac effects of CAR T-cell therapy. Case reports and series suggest that major adverse cardiovascular events are not uncommon after CAR T-cell therapy; however, limited data exist regarding incidence, pathophysiology, and prevention str...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580078/ https://www.ncbi.nlm.nih.gov/pubmed/36254553 http://dx.doi.org/10.1177/15330338221132927 |
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author | Dalal, Prarthana J. Patel, Nikita P. Feinstein, Matthew J. Akhter, Nausheen |
author_facet | Dalal, Prarthana J. Patel, Nikita P. Feinstein, Matthew J. Akhter, Nausheen |
author_sort | Dalal, Prarthana J. |
collection | PubMed |
description | This review summarizes the current literature on the adverse cardiac effects of CAR T-cell therapy. Case reports and series suggest that major adverse cardiovascular events are not uncommon after CAR T-cell therapy; however, limited data exist regarding incidence, pathophysiology, and prevention strategies related to CAR T-associated cardiovascular events. As cellular therapy advances and the indications for its use continue to expand, it is essential to better understand its associated cardiovascular toxicities. Biomarkers, cardiac imaging, longitudinal data from larger populations, and translational research are all essential areas for further research. Interestingly, CAR T-cell therapy can also be used to reverse cardiac fibrosis in murine models. Altogether this underscores the need to broadly understand how T-cells, endogenous and engineered, may impact cardiovascular diseases. |
format | Online Article Text |
id | pubmed-9580078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-95800782022-10-20 Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions Dalal, Prarthana J. Patel, Nikita P. Feinstein, Matthew J. Akhter, Nausheen Technol Cancer Res Treat Advances in CAR-T cell Therapies for Cancer This review summarizes the current literature on the adverse cardiac effects of CAR T-cell therapy. Case reports and series suggest that major adverse cardiovascular events are not uncommon after CAR T-cell therapy; however, limited data exist regarding incidence, pathophysiology, and prevention strategies related to CAR T-associated cardiovascular events. As cellular therapy advances and the indications for its use continue to expand, it is essential to better understand its associated cardiovascular toxicities. Biomarkers, cardiac imaging, longitudinal data from larger populations, and translational research are all essential areas for further research. Interestingly, CAR T-cell therapy can also be used to reverse cardiac fibrosis in murine models. Altogether this underscores the need to broadly understand how T-cells, endogenous and engineered, may impact cardiovascular diseases. SAGE Publications 2022-10-18 /pmc/articles/PMC9580078/ /pubmed/36254553 http://dx.doi.org/10.1177/15330338221132927 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Advances in CAR-T cell Therapies for Cancer Dalal, Prarthana J. Patel, Nikita P. Feinstein, Matthew J. Akhter, Nausheen Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title | Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title_full | Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title_fullStr | Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title_full_unstemmed | Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title_short | Adverse Cardiac Effects of CAR T-Cell Therapy: Characteristics, Surveillance, Management, and Future Research Directions |
title_sort | adverse cardiac effects of car t-cell therapy: characteristics, surveillance, management, and future research directions |
topic | Advances in CAR-T cell Therapies for Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580078/ https://www.ncbi.nlm.nih.gov/pubmed/36254553 http://dx.doi.org/10.1177/15330338221132927 |
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