Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish

BACKGROUND: Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mechanism remains elusive. This study aims to investigate the effect of LRPAP1 defect on ocular refractive development and its involved mechanism. METHODS: A lrpap1 mutan...

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Detalles Bibliográficos
Autores principales: Liu, Shanshan, Chen, Ting, Chen, Binghao, Liu, Yijun, Lu, Xiaohe, Li, Jiali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580148/
https://www.ncbi.nlm.nih.gov/pubmed/36261846
http://dx.doi.org/10.1186/s12964-022-00970-9

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