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Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis

Neuronal damage is the primary cause of long-term disability of multiple sclerosis (MS) patients. Assessment of axonal integrity from diffusion MRI parameters might enable better disease characterisation. 16 diffusion derived measurements from diffusion tensor imaging (DTI), diffusion kurtosis imagi...

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Autores principales: van der Weijden, Chris WJ, van der Hoorn, Anouk, Potze, Jan Hendrik, Renken, Remco J, Borra, Ronald JH, Dierckx, Rudi AJO, Gutmann, Ingomar W, Ouaalam, Hakim, Karimi, Davood, Gholipour, Ali, Warfield, Simon K, de Vries, Erik FJ, Meilof, Jan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580168/
https://www.ncbi.nlm.nih.gov/pubmed/35754351
http://dx.doi.org/10.1177/0271678X221107953
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author van der Weijden, Chris WJ
van der Hoorn, Anouk
Potze, Jan Hendrik
Renken, Remco J
Borra, Ronald JH
Dierckx, Rudi AJO
Gutmann, Ingomar W
Ouaalam, Hakim
Karimi, Davood
Gholipour, Ali
Warfield, Simon K
de Vries, Erik FJ
Meilof, Jan F
author_facet van der Weijden, Chris WJ
van der Hoorn, Anouk
Potze, Jan Hendrik
Renken, Remco J
Borra, Ronald JH
Dierckx, Rudi AJO
Gutmann, Ingomar W
Ouaalam, Hakim
Karimi, Davood
Gholipour, Ali
Warfield, Simon K
de Vries, Erik FJ
Meilof, Jan F
author_sort van der Weijden, Chris WJ
collection PubMed
description Neuronal damage is the primary cause of long-term disability of multiple sclerosis (MS) patients. Assessment of axonal integrity from diffusion MRI parameters might enable better disease characterisation. 16 diffusion derived measurements from diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and fixel-based analysis (FBA) in lesions, peri-lesion and normal appearing white matter were investigated. Diffusion MRI scans of 11 MS patients were processed to generate DTI, DKI, and FBA images. Fractional anisotropy (FA) and fibre density (FD) were used to assess axonal integrity across brain regions. Subsequently, 359 lesions were identified, and lesion and peri-lesion segmentation was performed using structural T(1)w, T(2)w, T(2)w-FLAIR, and T(1)w post-contrast MRI. The segmentations were then used to extract 16 diffusion MRI parameters from lesion, peri-lesion, and contralateral normal appearing white matter (NAWM). The measurements for axonal integrity, DTI-FA, DKI-FA, FBA-FD, produced similar results. All diffusion MRI parameters were affected in lesions as compared to NAWM (p < 0.001), confirming loss of axonal integrity in lesions. In peri-lesions, most parameters, except FBA-FD, were also significantly different from NAWM, although the effect size was smaller than in lesions. The reduction in axonal integrity in peri-lesions, despite unaffected fibre density estimates, suggests an effect of Wallerian degeneration.
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spelling pubmed-95801682022-10-20 Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis van der Weijden, Chris WJ van der Hoorn, Anouk Potze, Jan Hendrik Renken, Remco J Borra, Ronald JH Dierckx, Rudi AJO Gutmann, Ingomar W Ouaalam, Hakim Karimi, Davood Gholipour, Ali Warfield, Simon K de Vries, Erik FJ Meilof, Jan F J Cereb Blood Flow Metab Original Article Neuronal damage is the primary cause of long-term disability of multiple sclerosis (MS) patients. Assessment of axonal integrity from diffusion MRI parameters might enable better disease characterisation. 16 diffusion derived measurements from diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and fixel-based analysis (FBA) in lesions, peri-lesion and normal appearing white matter were investigated. Diffusion MRI scans of 11 MS patients were processed to generate DTI, DKI, and FBA images. Fractional anisotropy (FA) and fibre density (FD) were used to assess axonal integrity across brain regions. Subsequently, 359 lesions were identified, and lesion and peri-lesion segmentation was performed using structural T(1)w, T(2)w, T(2)w-FLAIR, and T(1)w post-contrast MRI. The segmentations were then used to extract 16 diffusion MRI parameters from lesion, peri-lesion, and contralateral normal appearing white matter (NAWM). The measurements for axonal integrity, DTI-FA, DKI-FA, FBA-FD, produced similar results. All diffusion MRI parameters were affected in lesions as compared to NAWM (p < 0.001), confirming loss of axonal integrity in lesions. In peri-lesions, most parameters, except FBA-FD, were also significantly different from NAWM, although the effect size was smaller than in lesions. The reduction in axonal integrity in peri-lesions, despite unaffected fibre density estimates, suggests an effect of Wallerian degeneration. SAGE Publications 2022-06-25 2022-11 /pmc/articles/PMC9580168/ /pubmed/35754351 http://dx.doi.org/10.1177/0271678X221107953 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
van der Weijden, Chris WJ
van der Hoorn, Anouk
Potze, Jan Hendrik
Renken, Remco J
Borra, Ronald JH
Dierckx, Rudi AJO
Gutmann, Ingomar W
Ouaalam, Hakim
Karimi, Davood
Gholipour, Ali
Warfield, Simon K
de Vries, Erik FJ
Meilof, Jan F
Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title_full Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title_fullStr Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title_full_unstemmed Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title_short Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
title_sort diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580168/
https://www.ncbi.nlm.nih.gov/pubmed/35754351
http://dx.doi.org/10.1177/0271678X221107953
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