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Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI

Chemical-exchange spin-lock (CESL) MRI can map regional uptake and utilisation of glucose in the brain at high spatial resolution (i.e sub 0.2 mm(3) voxels). We propose two quantitative kinetic models to describe glucose-induced changes in tissue R(1ρ) and apply them to glucoCESL MRI data acquired i...

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Autores principales: Dickie, Ben R, Jin, Tao, Wang, Ping, Hinz, Rainer, Harris, William, Boutin, Hervé, Parker, Geoff JM, Parkes, Laura M, Matthews, Julian C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580170/
https://www.ncbi.nlm.nih.gov/pubmed/35748031
http://dx.doi.org/10.1177/0271678X221108841
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author Dickie, Ben R
Jin, Tao
Wang, Ping
Hinz, Rainer
Harris, William
Boutin, Hervé
Parker, Geoff JM
Parkes, Laura M
Matthews, Julian C
author_facet Dickie, Ben R
Jin, Tao
Wang, Ping
Hinz, Rainer
Harris, William
Boutin, Hervé
Parker, Geoff JM
Parkes, Laura M
Matthews, Julian C
author_sort Dickie, Ben R
collection PubMed
description Chemical-exchange spin-lock (CESL) MRI can map regional uptake and utilisation of glucose in the brain at high spatial resolution (i.e sub 0.2 mm(3) voxels). We propose two quantitative kinetic models to describe glucose-induced changes in tissue R(1ρ) and apply them to glucoCESL MRI data acquired in tumour-bearing and healthy rats. When assuming glucose transport is saturable, the maximal transport capacity (T(max)) measured in normal tissue was 3.2 ± 0.6 µmol/min/mL, the half saturation constant (K(t)) was 8.8 ± 2.2 mM, the metabolic rate of glucose consumption (MR(glc)) was 0.21 ± 0.13 µmol/min/mL, and the cerebral blood volume (v(b)) was 0.006 ± 0.005 mL/mL. Values in tumour were: T(max) = 7.1 ± 2.7 µmol/min/mL, K(t) = 14 ± 1.7 mM, MR(glc) = 0.22 ± 0.09 µmol/min/mL, v(b) = 0.030 ± 0.035 mL/mL. T(max) and K(t) were significantly higher in tumour tissue than normal tissue (p = 0.006 and p = 0.011, respectively). When assuming glucose uptake also occurs via free diffusion, the free diffusion rate (k(d)) was 0.061 ± 0.017 mL/min/mL in normal tissue and 0.12 ± 0.042 mL/min/mL in tumour. These parameter estimates agree well with literature values obtained using other approaches (e.g. NMR spectroscopy).
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spelling pubmed-95801702022-10-20 Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI Dickie, Ben R Jin, Tao Wang, Ping Hinz, Rainer Harris, William Boutin, Hervé Parker, Geoff JM Parkes, Laura M Matthews, Julian C J Cereb Blood Flow Metab Original Articles Chemical-exchange spin-lock (CESL) MRI can map regional uptake and utilisation of glucose in the brain at high spatial resolution (i.e sub 0.2 mm(3) voxels). We propose two quantitative kinetic models to describe glucose-induced changes in tissue R(1ρ) and apply them to glucoCESL MRI data acquired in tumour-bearing and healthy rats. When assuming glucose transport is saturable, the maximal transport capacity (T(max)) measured in normal tissue was 3.2 ± 0.6 µmol/min/mL, the half saturation constant (K(t)) was 8.8 ± 2.2 mM, the metabolic rate of glucose consumption (MR(glc)) was 0.21 ± 0.13 µmol/min/mL, and the cerebral blood volume (v(b)) was 0.006 ± 0.005 mL/mL. Values in tumour were: T(max) = 7.1 ± 2.7 µmol/min/mL, K(t) = 14 ± 1.7 mM, MR(glc) = 0.22 ± 0.09 µmol/min/mL, v(b) = 0.030 ± 0.035 mL/mL. T(max) and K(t) were significantly higher in tumour tissue than normal tissue (p = 0.006 and p = 0.011, respectively). When assuming glucose uptake also occurs via free diffusion, the free diffusion rate (k(d)) was 0.061 ± 0.017 mL/min/mL in normal tissue and 0.12 ± 0.042 mL/min/mL in tumour. These parameter estimates agree well with literature values obtained using other approaches (e.g. NMR spectroscopy). SAGE Publications 2022-06-23 2022-11 /pmc/articles/PMC9580170/ /pubmed/35748031 http://dx.doi.org/10.1177/0271678X221108841 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Dickie, Ben R
Jin, Tao
Wang, Ping
Hinz, Rainer
Harris, William
Boutin, Hervé
Parker, Geoff JM
Parkes, Laura M
Matthews, Julian C
Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title_full Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title_fullStr Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title_full_unstemmed Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title_short Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI
title_sort quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucocesl mri
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580170/
https://www.ncbi.nlm.nih.gov/pubmed/35748031
http://dx.doi.org/10.1177/0271678X221108841
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