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Association between common laboratory indices and IgAV recurrence in children
BACKGROUND: IgA vasculitis (IgAV) is a common type of vasculitis seen in children. IgAV recurrence can result in chronic kidney disease. We aimed to explore the association between common laboratory indices and IgAV recurrence in children, and to establish a prediction model. METHODS: This retrospec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580187/ https://www.ncbi.nlm.nih.gov/pubmed/36258161 http://dx.doi.org/10.1186/s12887-022-03657-9 |
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author | Zhou, Juan Li, Li Luo, Jing Yang, Yingtian Shen, Xing |
author_facet | Zhou, Juan Li, Li Luo, Jing Yang, Yingtian Shen, Xing |
author_sort | Zhou, Juan |
collection | PubMed |
description | BACKGROUND: IgA vasculitis (IgAV) is a common type of vasculitis seen in children. IgAV recurrence can result in chronic kidney disease. We aimed to explore the association between common laboratory indices and IgAV recurrence in children, and to establish a prediction model. METHODS: This retrospective study included children with diagnosed with IgAV hospitalized in Bazhong Central Hospital, Sichuan, from January 2014 to December 2019. Children were assigned to two groups based on IgAV recurrence, and baseline clinical data were collected for comparison. A logistic regression model to predict IgAV recurrence was established. The receiver operating characteristic curve was plotted. The area under the curve (AUC) was used to detect performance of the predictive model. RESULTS: This study included 193 children (39 [20.2%], recurrence group; 154 [79.8%], non-recurrence group). Based on multivariate regression analysis, the duration of illness and joint involvement were independent predictors of IgAV recurrence in children (P < 0.05). No significant differences were observed in common laboratory indices (P > 0.05). The AUC of the prediction model was 0.766 (P < 0.001) with sensitivity of 74.4% and specificity of 68.8%. CONCLUSION: Common laboratory indices were not associated with recurrence of IgAV in children. |
format | Online Article Text |
id | pubmed-9580187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95801872022-10-20 Association between common laboratory indices and IgAV recurrence in children Zhou, Juan Li, Li Luo, Jing Yang, Yingtian Shen, Xing BMC Pediatr Research BACKGROUND: IgA vasculitis (IgAV) is a common type of vasculitis seen in children. IgAV recurrence can result in chronic kidney disease. We aimed to explore the association between common laboratory indices and IgAV recurrence in children, and to establish a prediction model. METHODS: This retrospective study included children with diagnosed with IgAV hospitalized in Bazhong Central Hospital, Sichuan, from January 2014 to December 2019. Children were assigned to two groups based on IgAV recurrence, and baseline clinical data were collected for comparison. A logistic regression model to predict IgAV recurrence was established. The receiver operating characteristic curve was plotted. The area under the curve (AUC) was used to detect performance of the predictive model. RESULTS: This study included 193 children (39 [20.2%], recurrence group; 154 [79.8%], non-recurrence group). Based on multivariate regression analysis, the duration of illness and joint involvement were independent predictors of IgAV recurrence in children (P < 0.05). No significant differences were observed in common laboratory indices (P > 0.05). The AUC of the prediction model was 0.766 (P < 0.001) with sensitivity of 74.4% and specificity of 68.8%. CONCLUSION: Common laboratory indices were not associated with recurrence of IgAV in children. BioMed Central 2022-10-19 /pmc/articles/PMC9580187/ /pubmed/36258161 http://dx.doi.org/10.1186/s12887-022-03657-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhou, Juan Li, Li Luo, Jing Yang, Yingtian Shen, Xing Association between common laboratory indices and IgAV recurrence in children |
title | Association between common laboratory indices and IgAV recurrence in children |
title_full | Association between common laboratory indices and IgAV recurrence in children |
title_fullStr | Association between common laboratory indices and IgAV recurrence in children |
title_full_unstemmed | Association between common laboratory indices and IgAV recurrence in children |
title_short | Association between common laboratory indices and IgAV recurrence in children |
title_sort | association between common laboratory indices and igav recurrence in children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580187/ https://www.ncbi.nlm.nih.gov/pubmed/36258161 http://dx.doi.org/10.1186/s12887-022-03657-9 |
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