Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals

The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national...

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Autores principales: Andeweg, Stijn P., Vennema, Harry, Veldhuijzen, Irene, Smorenburg, Naomi, Schmitz, Dennis, Zwagemaker, Florian, van Gageldonk-Lafeber, Arianne B., Hahné, Susan J. M., Reusken, Chantal, Knol, Mirjam J., Eggink, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580257/
https://www.ncbi.nlm.nih.gov/pubmed/35862508
http://dx.doi.org/10.1126/scitranslmed.abn4338
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author Andeweg, Stijn P.
Vennema, Harry
Veldhuijzen, Irene
Smorenburg, Naomi
Schmitz, Dennis
Zwagemaker, Florian
van Gageldonk-Lafeber, Arianne B.
Hahné, Susan J. M.
Reusken, Chantal
Knol, Mirjam J.
Eggink, Dirk
author_facet Andeweg, Stijn P.
Vennema, Harry
Veldhuijzen, Irene
Smorenburg, Naomi
Schmitz, Dennis
Zwagemaker, Florian
van Gageldonk-Lafeber, Arianne B.
Hahné, Susan J. M.
Reusken, Chantal
Knol, Mirjam J.
Eggink, Dirk
author_sort Andeweg, Stijn P.
collection PubMed
description The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared to the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14-59 days after complete vaccination compared to ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for re-infection with Beta, Gamma or Delta variants relative to Alpha variant in individuals with infection-induced immunity.
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spelling pubmed-95802572022-10-20 Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals Andeweg, Stijn P. Vennema, Harry Veldhuijzen, Irene Smorenburg, Naomi Schmitz, Dennis Zwagemaker, Florian van Gageldonk-Lafeber, Arianne B. Hahné, Susan J. M. Reusken, Chantal Knol, Mirjam J. Eggink, Dirk Sci Transl Med Reports The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared to the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14-59 days after complete vaccination compared to ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for re-infection with Beta, Gamma or Delta variants relative to Alpha variant in individuals with infection-induced immunity. American Association for the Advancement of Science 2022-07-21 /pmc/articles/PMC9580257/ /pubmed/35862508 http://dx.doi.org/10.1126/scitranslmed.abn4338 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Andeweg, Stijn P.
Vennema, Harry
Veldhuijzen, Irene
Smorenburg, Naomi
Schmitz, Dennis
Zwagemaker, Florian
van Gageldonk-Lafeber, Arianne B.
Hahné, Susan J. M.
Reusken, Chantal
Knol, Mirjam J.
Eggink, Dirk
Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title_full Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title_fullStr Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title_full_unstemmed Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title_short Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
title_sort elevated risk of infection with sars-cov-2 beta, gamma, and delta variant compared to alpha variant in vaccinated individuals
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580257/
https://www.ncbi.nlm.nih.gov/pubmed/35862508
http://dx.doi.org/10.1126/scitranslmed.abn4338
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