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A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

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A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein. Here we describe a new deep mutational scanning platform based on non-replicative pseudotyped lentiviruses that directly quantifies how large...

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Detalles Bibliográficos
Autores principales:	Dadonaite, Bernadeta, Crawford, Katharine H D, Radford, Caelan E, Farrell, Ariana G, Yu, Timothy C, Hannon, William W, Zhou, Panpan, Andrabi, Raiees, Burton, Dennis R, Liu, Lihong, Ho, David D., Neher, Richard A., Bloom, Jesse D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580381/ https://www.ncbi.nlm.nih.gov/pubmed/36263061 http://dx.doi.org/10.1101/2022.10.13.512056

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