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Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection

Oxysterols (i.e., oxidized cholesterol species) have complex roles in biology. 25-hydroxycholesterol (25HC), a product of activity of cholesterol-25-hydroxylase (CH25H) upon cholesterol, has recently been shown to be broadly antiviral, suggesting therapeutic potential against SARS-CoV-2. However, 25...

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Detalles Bibliográficos
Autores principales:	Fessler, Michael B., Madenspacher, Jennifer, Baker, Paul J., Hilligan, Kerry L., Castro, Ehydel, Meacham, Julie, Chen, Shih-Heng, Johnson, Reed F., Martin, Negin P., Tucker, C.J., Mahapatra, Debabrata, Cesta, Mark, Mayer-Barber, Katrin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580384/ https://www.ncbi.nlm.nih.gov/pubmed/36263064 http://dx.doi.org/10.1101/2022.09.12.507671

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