Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

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Transmission bottlenecks limit the spread of novel mutations and reduce the efficiency of natural selection along a transmission chain. Many viruses exhibit tight bottlenecks, and studies of early SARS-CoV-2 lineages identified a bottleneck of 1–3 infectious virions. While increased force of infecti...

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Detalles Bibliográficos
Autores principales: Bendall, Emily E., Callear, Amy, Getz, Amy, Goforth, Kendra, Edwards, Drew, Monto, Arnold S., Martin, Emily T., Lauring, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580385/
https://www.ncbi.nlm.nih.gov/pubmed/36263068
http://dx.doi.org/10.1101/2022.10.12.511991

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