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A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems

In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. Retrospective cohort study. 2406 (THS n = 886; SHI n = 1520) cri...

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Autores principales: Wernly, Bernhard, Flaatten, Hans, Beil, Michael, Fjølner, Jesper, Bruno, Raphael Romano, Artigas, Antonio, Pinto, Bernardo Bollen, Schefold, Joerg C., Kelm, Malte, Sigal, Sviri, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Rezar, Richard, Oeyen, Sandra, Wolff, Georg, Marsh, Brian, Andersen, Finn H., Moreno, Rui, Wernly, Sarah, Leaver, Susannah, Boumendil, Ariane, De Lange, Dylan W., Guidet, Bertrand, Perings, Stefan, Jung, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580441/
https://www.ncbi.nlm.nih.gov/pubmed/36261587
http://dx.doi.org/10.1038/s41598-022-21580-y
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author Wernly, Bernhard
Flaatten, Hans
Beil, Michael
Fjølner, Jesper
Bruno, Raphael Romano
Artigas, Antonio
Pinto, Bernardo Bollen
Schefold, Joerg C.
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Rezar, Richard
Oeyen, Sandra
Wolff, Georg
Marsh, Brian
Andersen, Finn H.
Moreno, Rui
Wernly, Sarah
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W.
Guidet, Bertrand
Perings, Stefan
Jung, Christian
author_facet Wernly, Bernhard
Flaatten, Hans
Beil, Michael
Fjølner, Jesper
Bruno, Raphael Romano
Artigas, Antonio
Pinto, Bernardo Bollen
Schefold, Joerg C.
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Rezar, Richard
Oeyen, Sandra
Wolff, Georg
Marsh, Brian
Andersen, Finn H.
Moreno, Rui
Wernly, Sarah
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W.
Guidet, Bertrand
Perings, Stefan
Jung, Christian
author_sort Wernly, Bernhard
collection PubMed
description In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. Retrospective cohort study. 2406 (THS n = 886; SHI n = 1520) critically ill ≥ 70 years patients in 129 ICUs. Generalized estimation equations with robust standard errors were chosen to create population average adjusted odds ratios (aOR). Data were adjusted for patient-specific variables, organ support and health economic data. The primary outcome was 30-day-mortality. Numerical differences between SHI and THS in SOFA scores (6 ± 3 vs. 5 ± 3; p = 0.002) were observed, but clinical frailty scores were similar (> 4; 17% vs. 14%; p = 0.09). Higher rates of renal replacement therapy (18% vs. 11%; p < 0.001) were found in SHI (aOR 0.61 95%CI 0.40–0.92; p = 0.02). No differences regarding intubation rates (68% vs. 70%; p = 0.33), vasopressor use (67% vs. 67%; p = 0.90) and 30-day-mortality rates (47% vs. 50%; p = 0.16) were found. Mortality remained similar between both systems after multivariable adjustment and sensitivity analyses. The retrospective character of this study. Baseline risk and mortality rates were similar between SHI and THS. The type of health care system does not appear to have played a role in the intensive care treatment of critically ill patients ≥ 70 years with COVID-19 in Europe.
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spelling pubmed-95804412022-10-19 A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems Wernly, Bernhard Flaatten, Hans Beil, Michael Fjølner, Jesper Bruno, Raphael Romano Artigas, Antonio Pinto, Bernardo Bollen Schefold, Joerg C. Kelm, Malte Sigal, Sviri van Heerden, Peter Vernon Szczeklik, Wojciech Elhadi, Muhammed Joannidis, Michael Rezar, Richard Oeyen, Sandra Wolff, Georg Marsh, Brian Andersen, Finn H. Moreno, Rui Wernly, Sarah Leaver, Susannah Boumendil, Ariane De Lange, Dylan W. Guidet, Bertrand Perings, Stefan Jung, Christian Sci Rep Article In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. Retrospective cohort study. 2406 (THS n = 886; SHI n = 1520) critically ill ≥ 70 years patients in 129 ICUs. Generalized estimation equations with robust standard errors were chosen to create population average adjusted odds ratios (aOR). Data were adjusted for patient-specific variables, organ support and health economic data. The primary outcome was 30-day-mortality. Numerical differences between SHI and THS in SOFA scores (6 ± 3 vs. 5 ± 3; p = 0.002) were observed, but clinical frailty scores were similar (> 4; 17% vs. 14%; p = 0.09). Higher rates of renal replacement therapy (18% vs. 11%; p < 0.001) were found in SHI (aOR 0.61 95%CI 0.40–0.92; p = 0.02). No differences regarding intubation rates (68% vs. 70%; p = 0.33), vasopressor use (67% vs. 67%; p = 0.90) and 30-day-mortality rates (47% vs. 50%; p = 0.16) were found. Mortality remained similar between both systems after multivariable adjustment and sensitivity analyses. The retrospective character of this study. Baseline risk and mortality rates were similar between SHI and THS. The type of health care system does not appear to have played a role in the intensive care treatment of critically ill patients ≥ 70 years with COVID-19 in Europe. Nature Publishing Group UK 2022-10-19 /pmc/articles/PMC9580441/ /pubmed/36261587 http://dx.doi.org/10.1038/s41598-022-21580-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wernly, Bernhard
Flaatten, Hans
Beil, Michael
Fjølner, Jesper
Bruno, Raphael Romano
Artigas, Antonio
Pinto, Bernardo Bollen
Schefold, Joerg C.
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Szczeklik, Wojciech
Elhadi, Muhammed
Joannidis, Michael
Rezar, Richard
Oeyen, Sandra
Wolff, Georg
Marsh, Brian
Andersen, Finn H.
Moreno, Rui
Wernly, Sarah
Leaver, Susannah
Boumendil, Ariane
De Lange, Dylan W.
Guidet, Bertrand
Perings, Stefan
Jung, Christian
A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title_full A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title_fullStr A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title_full_unstemmed A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title_short A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
title_sort retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in european tax-based healthcare systems (ths) versus social health insurance systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580441/
https://www.ncbi.nlm.nih.gov/pubmed/36261587
http://dx.doi.org/10.1038/s41598-022-21580-y
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