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One step synthesis of unsymmetrical 1,3-disubstituted BCP ketones via nickel/photoredox-catalyzed [1.1.1]propellane multicomponent dicarbofunctionalization

Bicyclo[1.1.1]pentanes (BCPs), utilized as sp(3)-rich bioisosteres for tert-butyl- and aryl groups as well as internal alkynes, have gained considerable momentum in drug development programs. Although many elegant methods have been developed to access BCP amines and BCP aryls efficiently, the method...

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Detalles Bibliográficos
Autores principales: Huang, Weichen, Keess, Sebastian, Molander, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580470/
https://www.ncbi.nlm.nih.gov/pubmed/36320918
http://dx.doi.org/10.1039/d2sc05100a

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