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Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients

We conducted a cross-sectional study to evaluate the role of serum levels of CA125 and HE4 in predicting optimal cytoreductive surgery. Eligible women who had been diagnosed with ovarian cancer based on both clinical and imaging criteria were enrolled in this study. Serum levels of CA 125 and HE4 we...

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Detalles Bibliográficos
Autores principales: Saffarieh, Elham, Nassiri, Setare, Mirmohammadkhani, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580533/
https://www.ncbi.nlm.nih.gov/pubmed/35916763
http://dx.doi.org/10.4081/ejtm.2022.10671
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author Saffarieh, Elham
Nassiri, Setare
Mirmohammadkhani, Majid
author_facet Saffarieh, Elham
Nassiri, Setare
Mirmohammadkhani, Majid
author_sort Saffarieh, Elham
collection PubMed
description We conducted a cross-sectional study to evaluate the role of serum levels of CA125 and HE4 in predicting optimal cytoreductive surgery. Eligible women who had been diagnosed with ovarian cancer based on both clinical and imaging criteria were enrolled in this study. Serum levels of CA 125 and HE4 were checked before surgery and all patients underwent complete surgical staging. After completion of the pathological evaluation, data were entered in SPSS version 23. One hundred and ten individuals were enrolled in our study. We divided cases between two groups: stage I to Ш b and stage Шc to IV. Serum level of HE4 >170 pmol/L can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%) and serum level of CA 125 > 320 UI/mL can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%). Our data demonstrated a negative predictive value of about 80% for both HE4 and CA125. Based on these cut-off, unnecessary surgery can be avoided in many cases, however, it is unwise to ignore clinical performance and radiological findings. Nevertheless, we can say the evaluation of tumor markers is feasible and helpful in predicting optimal surgery.
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spelling pubmed-95805332022-10-20 Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients Saffarieh, Elham Nassiri, Setare Mirmohammadkhani, Majid Eur J Transl Myol Article We conducted a cross-sectional study to evaluate the role of serum levels of CA125 and HE4 in predicting optimal cytoreductive surgery. Eligible women who had been diagnosed with ovarian cancer based on both clinical and imaging criteria were enrolled in this study. Serum levels of CA 125 and HE4 were checked before surgery and all patients underwent complete surgical staging. After completion of the pathological evaluation, data were entered in SPSS version 23. One hundred and ten individuals were enrolled in our study. We divided cases between two groups: stage I to Ш b and stage Шc to IV. Serum level of HE4 >170 pmol/L can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%) and serum level of CA 125 > 320 UI/mL can predict optimal cytoreductive surgery before operation. (sensitivity:80% and specificity 70%). Our data demonstrated a negative predictive value of about 80% for both HE4 and CA125. Based on these cut-off, unnecessary surgery can be avoided in many cases, however, it is unwise to ignore clinical performance and radiological findings. Nevertheless, we can say the evaluation of tumor markers is feasible and helpful in predicting optimal surgery. PAGEPress Publications, Pavia, Italy 2022-08-01 /pmc/articles/PMC9580533/ /pubmed/35916763 http://dx.doi.org/10.4081/ejtm.2022.10671 Text en https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Saffarieh, Elham
Nassiri, Setare
Mirmohammadkhani, Majid
Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title_full Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title_fullStr Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title_full_unstemmed Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title_short Predicting value of HE4 and CA125 markers for optimal cytoreductive surgery in ovarian cancer patients
title_sort predicting value of he4 and ca125 markers for optimal cytoreductive surgery in ovarian cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580533/
https://www.ncbi.nlm.nih.gov/pubmed/35916763
http://dx.doi.org/10.4081/ejtm.2022.10671
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