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Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes

Endometriosis-associated pain and the mechanisms responsible for its initiation and persistence are complex and difficult to treat. Endometriosis-associated pain is experienced as dysmenorrhea, cyclical pain related to organ function including dysuria, dyschezia and dyspareunia, and persistent pelvi...

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Autores principales: McNamara, Helen C., Frawley, Helena C., Donoghue, Jacqueline F., Readman, Emma, Healey, Martin, Ellett, Lenore, Reddington, Charlotte, Hicks, Lauren J., Harlow, Keryn, Rogers, Peter A. W., Cheng, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580702/
https://www.ncbi.nlm.nih.gov/pubmed/36303969
http://dx.doi.org/10.3389/frph.2021.729642
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author McNamara, Helen C.
Frawley, Helena C.
Donoghue, Jacqueline F.
Readman, Emma
Healey, Martin
Ellett, Lenore
Reddington, Charlotte
Hicks, Lauren J.
Harlow, Keryn
Rogers, Peter A. W.
Cheng, Claudia
author_facet McNamara, Helen C.
Frawley, Helena C.
Donoghue, Jacqueline F.
Readman, Emma
Healey, Martin
Ellett, Lenore
Reddington, Charlotte
Hicks, Lauren J.
Harlow, Keryn
Rogers, Peter A. W.
Cheng, Claudia
author_sort McNamara, Helen C.
collection PubMed
description Endometriosis-associated pain and the mechanisms responsible for its initiation and persistence are complex and difficult to treat. Endometriosis-associated pain is experienced as dysmenorrhea, cyclical pain related to organ function including dysuria, dyschezia and dyspareunia, and persistent pelvic pain. Pain symptomatology correlates poorly with the extent of macroscopic disease. In addition to the local effects of disease, endometriosis-associated pain develops as a product of peripheral sensitization, central sensitization and cross sensitization. Endometriosis-associated pain is further contributed to by comorbid pain conditions, such as bladder pain syndrome, irritable bowel syndrome, abdomino-pelvic myalgia and vulvodynia. This article will review endometriosis-associated pain, its mechanisms, and its comorbid pain syndromes with a view to aiding the clinician in navigating the literature and terminology of pain and pain syndromes. Limitations of our current understanding of endometriosis-associated pain will be acknowledged. Where possible, commonalities in pain mechanisms between endometriosis-associated pain and comorbid pain syndromes will be highlighted.
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spelling pubmed-95807022022-10-26 Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes McNamara, Helen C. Frawley, Helena C. Donoghue, Jacqueline F. Readman, Emma Healey, Martin Ellett, Lenore Reddington, Charlotte Hicks, Lauren J. Harlow, Keryn Rogers, Peter A. W. Cheng, Claudia Front Reprod Health Reproductive Health Endometriosis-associated pain and the mechanisms responsible for its initiation and persistence are complex and difficult to treat. Endometriosis-associated pain is experienced as dysmenorrhea, cyclical pain related to organ function including dysuria, dyschezia and dyspareunia, and persistent pelvic pain. Pain symptomatology correlates poorly with the extent of macroscopic disease. In addition to the local effects of disease, endometriosis-associated pain develops as a product of peripheral sensitization, central sensitization and cross sensitization. Endometriosis-associated pain is further contributed to by comorbid pain conditions, such as bladder pain syndrome, irritable bowel syndrome, abdomino-pelvic myalgia and vulvodynia. This article will review endometriosis-associated pain, its mechanisms, and its comorbid pain syndromes with a view to aiding the clinician in navigating the literature and terminology of pain and pain syndromes. Limitations of our current understanding of endometriosis-associated pain will be acknowledged. Where possible, commonalities in pain mechanisms between endometriosis-associated pain and comorbid pain syndromes will be highlighted. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC9580702/ /pubmed/36303969 http://dx.doi.org/10.3389/frph.2021.729642 Text en Copyright © 2021 McNamara, Frawley, Donoghue, Readman, Healey, Ellett, Reddington, Hicks, Harlow, Rogers and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Reproductive Health
McNamara, Helen C.
Frawley, Helena C.
Donoghue, Jacqueline F.
Readman, Emma
Healey, Martin
Ellett, Lenore
Reddington, Charlotte
Hicks, Lauren J.
Harlow, Keryn
Rogers, Peter A. W.
Cheng, Claudia
Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title_full Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title_fullStr Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title_full_unstemmed Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title_short Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
title_sort peripheral, central, and cross sensitization in endometriosis-associated pain and comorbid pain syndromes
topic Reproductive Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580702/
https://www.ncbi.nlm.nih.gov/pubmed/36303969
http://dx.doi.org/10.3389/frph.2021.729642
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