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HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report

Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeate...

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Detalles Bibliográficos
Autores principales: Liest, Sara, Riishede Christiansen, Iben, Prætorius, Lisbeth, Bogstad, Jeanette, Freiesleben, Nina la Cour, Pinborg, Anja, Løssl, Kristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580704/
https://www.ncbi.nlm.nih.gov/pubmed/36303957
http://dx.doi.org/10.3389/frph.2021.764299
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author Liest, Sara
Riishede Christiansen, Iben
Prætorius, Lisbeth
Bogstad, Jeanette
Freiesleben, Nina la Cour
Pinborg, Anja
Løssl, Kristine
author_facet Liest, Sara
Riishede Christiansen, Iben
Prætorius, Lisbeth
Bogstad, Jeanette
Freiesleben, Nina la Cour
Pinborg, Anja
Løssl, Kristine
author_sort Liest, Sara
collection PubMed
description Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeated oocyte pickup 36 h later. Failed GnRH agonist trigger is frustrating and unsatisfactory, and fertility doctors must be aware of possible hCG retriggering and retained opportunity for successful cycle outcome. Objective: In this case report, we present a woman who experienced failed GnRH agonist trigger and rescue hCG retrigger followed by two consecutive live births after frozen-thawed single blastocyst transfers. Methods: A case report. Results: Two healthy children were born in 2018 and 2020, respectively as a result of controlled ovarian stimulation for IVF, failed GnRH agonist trigger followed by hCG re-trigger, and successful retrieval of 25 oocytes. Conclusion: Retriggering with hCG after failed GnRH agonist trigger can result in consecutive live births, and such knowledge can prevent cycle cancellation and patient discouragement. Knowledge on retriggering with hCG and consecutive live births after failed GnRH agonist trigger can prevent cycle cancellation and patient discouragement.
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spelling pubmed-95807042022-10-26 HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report Liest, Sara Riishede Christiansen, Iben Prætorius, Lisbeth Bogstad, Jeanette Freiesleben, Nina la Cour Pinborg, Anja Løssl, Kristine Front Reprod Health Reproductive Health Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeated oocyte pickup 36 h later. Failed GnRH agonist trigger is frustrating and unsatisfactory, and fertility doctors must be aware of possible hCG retriggering and retained opportunity for successful cycle outcome. Objective: In this case report, we present a woman who experienced failed GnRH agonist trigger and rescue hCG retrigger followed by two consecutive live births after frozen-thawed single blastocyst transfers. Methods: A case report. Results: Two healthy children were born in 2018 and 2020, respectively as a result of controlled ovarian stimulation for IVF, failed GnRH agonist trigger followed by hCG re-trigger, and successful retrieval of 25 oocytes. Conclusion: Retriggering with hCG after failed GnRH agonist trigger can result in consecutive live births, and such knowledge can prevent cycle cancellation and patient discouragement. Knowledge on retriggering with hCG and consecutive live births after failed GnRH agonist trigger can prevent cycle cancellation and patient discouragement. Frontiers Media S.A. 2021-10-27 /pmc/articles/PMC9580704/ /pubmed/36303957 http://dx.doi.org/10.3389/frph.2021.764299 Text en Copyright © 2021 Liest, Riishede Christiansen, Prætorius, Bogstad, Freiesleben, Pinborg and Løssl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Reproductive Health
Liest, Sara
Riishede Christiansen, Iben
Prætorius, Lisbeth
Bogstad, Jeanette
Freiesleben, Nina la Cour
Pinborg, Anja
Løssl, Kristine
HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title_full HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title_fullStr HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title_full_unstemmed HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title_short HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
title_sort hcg trigger after failed gnrh agonist trigger resulted in two consecutive live births: a case report
topic Reproductive Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580704/
https://www.ncbi.nlm.nih.gov/pubmed/36303957
http://dx.doi.org/10.3389/frph.2021.764299
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