Cargando…

Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis

Endometriosis (EM) is characterized by the growth of endometrium-like tissue outside the uterus, leading to chronic inflammation and pelvic pain. Lesion proliferation, vascularization, and associated inflammation are the hallmark features of EM lesions. The legalization of recreational cannabinoids...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lingegowda, Harshavardhan, Miller, Jessica E., Marks, Ryan M., Symons, Lindsey K., Alward, Taylor, Lomax, Alan E., Koti, Madhuri, Tayade, Chandrakant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Reproductive Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580784/ https://www.ncbi.nlm.nih.gov/pubmed/36304004 http://dx.doi.org/10.3389/frph.2021.726936

Ejemplares similares

Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
por: Lingegowda, Harshavardhan, et al.
Publicado: (2022)

IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis
por: Miller, Jessica E., et al.
Publicado: (2021)

Insights Into Extracellular Vesicle/Exosome and miRNA Mediated Bi-Directional Communication During Porcine Pregnancy
por: Bidarimath, Mallikarjun, et al.
Publicado: (2021)

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain
por: Marchalant, Y, et al.
Publicado: (2009)

Role of Nitric Oxide in the Antipruritic Effect of WIN 55,212-2, a Cannabinoid Agonist
por: Gercek, Oyku Zeynep, et al.
Publicado: (2020)

Cannabinoid WIN55,212-2 reprograms monocytes and macrophages to inhibit LPS-induced inflammation
por: Pérez-Diego, Mario, et al.
Publicado: (2023)

Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice
por: Aguilar, María A., et al.
Publicado: (2017)

The cannabinoid WIN 55,212-2 prevents neuroendocrine differentiation of LNCaP prostate cancer cells
por: Morell, C, et al.
Publicado: (2016)

Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response
por: Hernández-Cervantes, Rosalía, et al.
Publicado: (2019)

Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2
por: Chavez-Monteagudo, Julio Raul, et al.
Publicado: (2022)

A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction
por: Cajiao-Manrique, María del Mar, et al.
Publicado: (2023)

Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology
por: McCallion, Alison, et al.
Publicado: (2022)

Implications of immune dysfunction on endometriosis associated infertility
por: Miller, Jessica E., et al.
Publicado: (2016)

IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis
por: Miller, Jessica E., et al.
Publicado: (2020)

Microinjection of WIN55,212-2 as A Cannabinoid Agonist into The Basolateral Amygdala Induces Sensitization to Morphine in Rats
por: Molaei, Marzieh, et al.
Publicado: (2014)

Consequences of Adolescent Exposure to the Cannabinoid Receptor Agonist WIN55,212-2 on Working Memory in Female Rats
por: Kirschmann, Erin K., et al.
Publicado: (2017)

Dose-dependent effect of cannabinoid WIN-55,212-2 on myelin repair following a demyelinating insult
por: Tomas-Roig, J., et al.
Publicado: (2020)

Cannabinoid receptor agonist WIN55212-2 reduces unpredictable mild stress-induced depressive behavior of rats
por: Zhong, Chao-Chao, et al.
Publicado: (2021)

The dysregulation of leukemia inhibitory factor and its implications for endometriosis pathophysiology
por: Zutautas, Katherine B., et al.
Publicado: (2023)

Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2
por: Scholl, Antje, et al.
Publicado: (2016)

The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats
por: Jahanabadi, Samane, et al.
Publicado: (2016)

Cannabinoid WIN 55,212-2 Inhibits Human Glioma Cell Growth by Triggering ROS-Mediated Signal Pathways
por: Wang, Kun, et al.
Publicado: (2021)

Cannabinoid Analogue WIN 55212–2 Protects Paraquat-Induced Lung Injury and Enhances Macrophage M2 Polarization
por: He, Quan, et al.
Publicado: (2022)

Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
por: Manzanedo, Carmen, et al.
Publicado: (2010)

The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
por: Paulsen, Katrin, et al.
Publicado: (2011)

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β(1-42) Effects on Astrocytes in Primary Culture
por: Aguirre-Rueda, Diana, et al.
Publicado: (2015)

WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels
por: An, Dongchen, et al.
Publicado: (2021)

Retracted: Cannabinoid WIN 55,212-2 Inhibits Human Glioma Cell Growth by Triggering ROS-Mediated Signal Pathways
por: International, BioMed Research
Publicado: (2023)

MON-008 Estrogen-Responsive and -Unresponsive Gene Expressions Promoted by Enhancers Specifically Hypomethylated in Endometriotic Cells May Become a Molecular Marker in Endometriosis Lesions
por: Izawa, Masao, et al.
Publicado: (2020)

ODP403 Diversity of Estrogen-Responsive Genes in Endometriotic Lesions
por: Izawa, Masao, et al.
Publicado: (2022)

l-Arginine stimulates intestinal intraepithelial lymphocyte functions and immune response in chickens orally immunized with live intermediate plus strain of infectious bursal disease vaccine
por: Tayade, Chandrakant, et al.
Publicado: (2006)

Behavioral and Neurochemical Changes in Mesostriatal Dopaminergic Regions of the Rat after Chronic Administration of the Cannabinoid Receptor Agonist WIN55,212-2
por: Fanarioti, Eleni, et al.
Publicado: (2015)

Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait
por: Rodríguez-Arias, M., et al.
Publicado: (2016)

Interleukin-33 modulates inflammation in endometriosis
por: Miller, Jessica E., et al.
Publicado: (2017)

Molecular Background of Estrogen-Dependent and -Independent Gene Expressions in Endometriotic Lesions
por: Izawa, Masao, et al.
Publicado: (2021)

Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1
por: KONG, YING, et al.
Publicado: (2016)

Corrigendum to “Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait”
por: Rodríguez-Arias, M., et al.
Publicado: (2016)

Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication
por: Allam, Sarah, et al.
Publicado: (2022)

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells
por: Wasik, A M, et al.
Publicado: (2011)

A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats
por: Goonawardena, Anushka V., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_fh31f0a5t63jk1ploah1kti95l