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Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580792/ https://www.ncbi.nlm.nih.gov/pubmed/36304045 http://dx.doi.org/10.3389/frph.2021.636771 |
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author | Vo, Kim Cat Tuyen Kawamura, Kazuhiro |
author_facet | Vo, Kim Cat Tuyen Kawamura, Kazuhiro |
author_sort | Vo, Kim Cat Tuyen |
collection | PubMed |
description | Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan. |
format | Online Article Text |
id | pubmed-9580792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95807922022-10-26 Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan Vo, Kim Cat Tuyen Kawamura, Kazuhiro Front Reprod Health Reproductive Health Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC9580792/ /pubmed/36304045 http://dx.doi.org/10.3389/frph.2021.636771 Text en Copyright © 2021 Vo and Kawamura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Reproductive Health Vo, Kim Cat Tuyen Kawamura, Kazuhiro Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title | Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title_full | Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title_fullStr | Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title_full_unstemmed | Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title_short | Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan |
title_sort | ovarian fragmentation and akt stimulation for expansion of fertile lifespan |
topic | Reproductive Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580792/ https://www.ncbi.nlm.nih.gov/pubmed/36304045 http://dx.doi.org/10.3389/frph.2021.636771 |
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