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Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapi...

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Autores principales: Vo, Kim Cat Tuyen, Kawamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580792/
https://www.ncbi.nlm.nih.gov/pubmed/36304045
http://dx.doi.org/10.3389/frph.2021.636771
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author Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
author_facet Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
author_sort Vo, Kim Cat Tuyen
collection PubMed
description Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan.
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spelling pubmed-95807922022-10-26 Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan Vo, Kim Cat Tuyen Kawamura, Kazuhiro Front Reprod Health Reproductive Health Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan. Frontiers Media S.A. 2021-03-02 /pmc/articles/PMC9580792/ /pubmed/36304045 http://dx.doi.org/10.3389/frph.2021.636771 Text en Copyright © 2021 Vo and Kawamura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Reproductive Health
Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title_full Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title_fullStr Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title_full_unstemmed Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title_short Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan
title_sort ovarian fragmentation and akt stimulation for expansion of fertile lifespan
topic Reproductive Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580792/
https://www.ncbi.nlm.nih.gov/pubmed/36304045
http://dx.doi.org/10.3389/frph.2021.636771
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