A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

Quantitative modeling is increasingly utilized in the drug discovery and development process, from the initial stages of target selection, through clinical studies. The modeling can provide guidance on three major questions–is this the right target, what are the right compound properties, and what i...

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Detalles Bibliográficos
Autores principales: Kapitanov, Georgi I., Chabot, Jeffrey R., Narula, Jatin, Roy, Mahua, Neubert, Hendrik, Palandra, Joe, Farrokhi, Vahid, Johnson, Jay S., Webster, Robert, Jones, Hannah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581070/
https://www.ncbi.nlm.nih.gov/pubmed/36303796
http://dx.doi.org/10.3389/fbinf.2021.731340

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