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Isolated nocturnal hypertension in relation to host and environmental factors and clock genes

Isolated nocturnal hypertension (INH) is a special type of out‐of‐office hypertension. Its determinants and pathophysiology remain unclear. In a nested case‐control study, we intend to investigate the host, environmental, and genetic factors in relation to INH. Among 2030 outpatients screened from D...

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Autores principales: Huang, Jian‐Feng, Zhang, Dong‐Yan, Sheng, Chang‐Sheng, An, De‐Wei, Li, Mingxuan, Cheng, Yi‐Bang, Guo, Qian‐Hui, Wang, Ying, Wang, Ji‐Guang, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581097/
https://www.ncbi.nlm.nih.gov/pubmed/35942908
http://dx.doi.org/10.1111/jch.14532
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author Huang, Jian‐Feng
Zhang, Dong‐Yan
Sheng, Chang‐Sheng
An, De‐Wei
Li, Mingxuan
Cheng, Yi‐Bang
Guo, Qian‐Hui
Wang, Ying
Wang, Ji‐Guang
Li, Yan
author_facet Huang, Jian‐Feng
Zhang, Dong‐Yan
Sheng, Chang‐Sheng
An, De‐Wei
Li, Mingxuan
Cheng, Yi‐Bang
Guo, Qian‐Hui
Wang, Ying
Wang, Ji‐Guang
Li, Yan
author_sort Huang, Jian‐Feng
collection PubMed
description Isolated nocturnal hypertension (INH) is a special type of out‐of‐office hypertension. Its determinants and pathophysiology remain unclear. In a nested case‐control study, we intend to investigate the host, environmental, and genetic factors in relation to INH. Among 2030 outpatients screened from December 2008 till June 2015, 128 patients with INH were identified, and then 128 normotensives were matched according to sex and age. INH was an elevated nocturnal blood pressure (BP ≥120/70 mmHg) in the presence of a normal daytime BP (< 135/85 mmHg). Host factors included age, sex, body mass index, smoking and drinking, sleep time and duration, heart rate, serum lipids, and serum creatinine. Environmental cues encompassed season, ambient temperature, atmospheric pressure, humidity, and wind speed, and genetic cues 29 single‐nucleotide polymorphisms (SNPs) in 12 clock genes. Daytime and nighttime BPs averaged 124.9/80.7  and 114.5/73.7 mmHg, respectively, in the INH patients and 121.0/76.5 and 101.8/63.3 mmHg in the normotensive controls. Stepwise logistic regression analyses revealed that INH was associated with nighttime heart rate (P = .0018), sleep duration (P = .0499), and relative humidity (P = .0747). The odds ratios (95% CI) for each 10 beats/min faster nighttime heart rate and 10% lower relative humidity were 1.82 (1.25‐2.65) and 0.82 (0.67‐1.00), respectively. Irrespective of the genetic models, no significant association was observed between INH and the SNPs (P ≥ .054). In conclusion, INH was associated with host and environmental factors rather than genetic markers.
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spelling pubmed-95810972022-10-20 Isolated nocturnal hypertension in relation to host and environmental factors and clock genes Huang, Jian‐Feng Zhang, Dong‐Yan Sheng, Chang‐Sheng An, De‐Wei Li, Mingxuan Cheng, Yi‐Bang Guo, Qian‐Hui Wang, Ying Wang, Ji‐Guang Li, Yan J Clin Hypertens (Greenwich) Nocturnal Hypertension Isolated nocturnal hypertension (INH) is a special type of out‐of‐office hypertension. Its determinants and pathophysiology remain unclear. In a nested case‐control study, we intend to investigate the host, environmental, and genetic factors in relation to INH. Among 2030 outpatients screened from December 2008 till June 2015, 128 patients with INH were identified, and then 128 normotensives were matched according to sex and age. INH was an elevated nocturnal blood pressure (BP ≥120/70 mmHg) in the presence of a normal daytime BP (< 135/85 mmHg). Host factors included age, sex, body mass index, smoking and drinking, sleep time and duration, heart rate, serum lipids, and serum creatinine. Environmental cues encompassed season, ambient temperature, atmospheric pressure, humidity, and wind speed, and genetic cues 29 single‐nucleotide polymorphisms (SNPs) in 12 clock genes. Daytime and nighttime BPs averaged 124.9/80.7  and 114.5/73.7 mmHg, respectively, in the INH patients and 121.0/76.5 and 101.8/63.3 mmHg in the normotensive controls. Stepwise logistic regression analyses revealed that INH was associated with nighttime heart rate (P = .0018), sleep duration (P = .0499), and relative humidity (P = .0747). The odds ratios (95% CI) for each 10 beats/min faster nighttime heart rate and 10% lower relative humidity were 1.82 (1.25‐2.65) and 0.82 (0.67‐1.00), respectively. Irrespective of the genetic models, no significant association was observed between INH and the SNPs (P ≥ .054). In conclusion, INH was associated with host and environmental factors rather than genetic markers. John Wiley and Sons Inc. 2022-08-09 /pmc/articles/PMC9581097/ /pubmed/35942908 http://dx.doi.org/10.1111/jch.14532 Text en © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Nocturnal Hypertension
Huang, Jian‐Feng
Zhang, Dong‐Yan
Sheng, Chang‐Sheng
An, De‐Wei
Li, Mingxuan
Cheng, Yi‐Bang
Guo, Qian‐Hui
Wang, Ying
Wang, Ji‐Guang
Li, Yan
Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title_full Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title_fullStr Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title_full_unstemmed Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title_short Isolated nocturnal hypertension in relation to host and environmental factors and clock genes
title_sort isolated nocturnal hypertension in relation to host and environmental factors and clock genes
topic Nocturnal Hypertension
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581097/
https://www.ncbi.nlm.nih.gov/pubmed/35942908
http://dx.doi.org/10.1111/jch.14532
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