Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction

The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery. The ICH S7B Guideline and Q&A on Clinical and Nonclinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential promotes...

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Detalles Bibliográficos
Autores principales: Trovato, Cristian, Mohr, Marcel, Schmidt, Friedemann, Passini, Elisa, Rodriguez, Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581132/
https://www.ncbi.nlm.nih.gov/pubmed/36278026
http://dx.doi.org/10.3389/ftox.2022.992650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581132/
https://www.ncbi.nlm.nih.gov/pubmed/36278026
http://dx.doi.org/10.3389/ftox.2022.992650

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