Cargando…

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models

Human Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy due to their potent capacity for tumor recognition and cytolysis of many tumor cell types. However, efforts to deploy clinical strategies for Vγ9Vδ2 T cell cancer therapy are hampered by insufficient potency. We are pursuing an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liou, Mei-Ling, Lahusen, Tyler, Li, Haishan, Xiao, Lingzhi, Pauza, C. David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581136/ https://www.ncbi.nlm.nih.gov/pubmed/36275712 http://dx.doi.org/10.3389/fimmu.2022.1012051

Ejemplares similares

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
por: Kim, Hee Yeon, et al.
Publicado: (2018)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
por: Gabriel, Heloisa B, et al.
Publicado: (2018)

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma
por: Abate, Mario, et al.
Publicado: (2017)

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
por: Jordão, Fabiana M, et al.
Publicado: (2013)

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
por: Ory, B, et al.
Publicado: (2008)

Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants
por: Guo, Dong, et al.
Publicado: (2015)

Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus
por: Samori, Petrus Yesaya, et al.
Publicado: (2017)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
por: Gong, Daoyong, et al.
Publicado: (2022)

Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues
por: Hou, Anwei, et al.
Publicado: (2021)

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
por: Zhang, Dongrui, et al.
Publicado: (2023)

Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local
por: Pauza, C. David, et al.
Publicado: (2018)

Cloning and Characterization of Farnesyl Diphosphate Synthase Gene Involved in Triterpenoids Biosynthesis from Poria cocos
por: Wang, Jianrong, et al.
Publicado: (2014)

Control of CD56 expression and tumor cell cytotoxicity in human Vγ2Vδ2 T cells
por: Urban, Elizabeth M, et al.
Publicado: (2009)

Biosynthesis of α-Bisabolol by Farnesyl Diphosphate Synthase and α-Bisabolol Synthase and Their Related Transcription Factors in Matricaria recutita L.
por: Tai, Yuling, et al.
Publicado: (2023)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase
por: Chan, Yueh-Te, et al.
Publicado: (2017)

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
por: Gadelha, Ana Paula R., et al.
Publicado: (2020)

Effects of 15-Deoxy-Δ(12,14)-Prostaglandin J2 (15d-PGJ2) and Rosiglitazone on Human Vδ2(+) T Cells
por: Li, Haishan, et al.
Publicado: (2009)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
por: Jin, Tingting, et al.
Publicado: (2022)

Concise synthesis of artemisinin from a farnesyl diphosphate analogue
por: Tang, Xiaoping, et al.
Publicado: (2018)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
por: Ha, Nguyen Thi, et al.
Publicado: (2020)

Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure
por: Li, Haishan, et al.
Publicado: (2020)

Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum
por: Nuttall, James M., et al.
Publicado: (2012)

Sesquiterpene Synthase‐Catalysed Formation of a New Medium‐Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues
por: Huynh, Florence, et al.
Publicado: (2018)

Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells
por: Oike, Asami, et al.
Publicado: (2022)

Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells
por: Wang, Lijuan, et al.
Publicado: (2023)

A cytosolic bifunctional geranyl/farnesyl diphosphate synthase provides MVA-derived GPP for geraniol biosynthesis in rose flowers
por: Conart, Corentin, et al.
Publicado: (2023)

Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum
por: Fei, Yu, et al.
Publicado: (2019)

Rational design of Lepidoptera-specific insecticidal inhibitors targeting farnesyl diphosphate synthase, a key enzyme of the juvenile hormone biosynthetic pathway
por: Picard, Marie-Ève, et al.
Publicado: (2021)

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
por: Pan, Jian-Jung, et al.
Publicado: (2015)

Inhibition of Coenzyme Qs Accumulation in Engineered Escherichia coli by High Concentration of Farnesyl Diphosphate
por: Samoudi, Mojtaba, et al.
Publicado: (2015)

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
por: Dehghani, Mehdi, et al.
Publicado: (2018)

Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase
por: Ohno, K, et al.
Publicado: (2011)

Interacting Targets of the Farnesyl of Transducin γ-Subunit
por: Katadae, Maiko, et al.
Publicado: (2008)

Safety and durability of AGT103-T autologous T cell therapy for HIV infection in a Phase 1 trial
por: Muvarak, Nidal, et al.
Publicado: (2022)

Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis
por: Zhao, Ruiyang, et al.
Publicado: (2021)

Renal Dysfunction due to Tenofovir-Diphosphate Inhibition of Mitochondrial Complex V (ATP Synthase)
por: Sluis-Cremer, Nicolas
Publicado: (2023)

Vγ9Vδ2 T cells expressing a BCMA—Specific chimeric antigen receptor inhibit multiple myeloma xenograft growth
por: Zhang, Xi, et al.
Publicado: (2022)

Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi
por: Wei, Guo, et al.
Publicado: (2020)

Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells
por: Gu, Siyi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_q3tsfese1ficj7tomf5bkeh3a0