Cargando…

A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft

BACKGROUND: For patients with osteoporotic vertebral compression fractures (OVCFs) treated with percutaneous kyphoplasty (PKP), the occurrence and risk factors of intradiscal cement leakage should be characteristic of the presence of intravertebral cleft (IVC). This study aimed to identify risk fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Ning, Wang, Tianyi, Wang, Aobo, Yuan, Shuo, Du, Peng, Si, Fangda, Zhu, Wenyi, Li, Jian, Zang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581225/
https://www.ncbi.nlm.nih.gov/pubmed/36277280
http://dx.doi.org/10.3389/fsurg.2022.1005220
_version_ 1784812572053078016
author Fan, Ning
Wang, Tianyi
Wang, Aobo
Yuan, Shuo
Du, Peng
Si, Fangda
Zhu, Wenyi
Li, Jian
Zang, Lei
author_facet Fan, Ning
Wang, Tianyi
Wang, Aobo
Yuan, Shuo
Du, Peng
Si, Fangda
Zhu, Wenyi
Li, Jian
Zang, Lei
author_sort Fan, Ning
collection PubMed
description BACKGROUND: For patients with osteoporotic vertebral compression fractures (OVCFs) treated with percutaneous kyphoplasty (PKP), the occurrence and risk factors of intradiscal cement leakage should be characteristic of the presence of intravertebral cleft (IVC). This study aimed to identify risk factors for intradiscal leakage in individuals with OVCFs combined with IVC treated with PKP and build a powered and well-calibrated predictive nomogram. METHODS: This study retrospectively reviewed consecutive patients who underwent PKP at our center between January 2016 and May 2021. Patients diagnosed with OVCFs combined with IVC were identified, and the incidence of different types of bone cement leakage was recorded. Risk factors for intradiscal leakage among the demographic, perioperative baseline, and radiologic data were identified, following which a nomogram was developed and verified. RESULTS: A total of 109 eligible patients were included, and the intradiscal leakage rate was 32.1%. Compression rate (odds ratio [OR] 0.025; 95% confidence interval [CI] 0.002–0.264; P = 0.002) and cemented vertebral body fraction (OR 44.122; 95% CI 2.790–697.740; P = 0.007) were identified as independent risk factors. A predictive nomogram with good predictive power (C-statistic = 0.786) and fitness of data (Hosmer–Lemeshow goodness-of-fit test, P = 0.092) was established to build a quantitative relationship between the risk factors and intradiscal leakage. CONCLUSION: The incidence rate of intradiscal leakage in PKP for OVCFs combined with IVC was 32.1%. Compression rate and cemented vertebral body fraction were identified as independent risk factors. A powered and well-calibrated nomogram was established to accurately predict the probability of intradiscal leakage. Further prospective and multicenter studies are required to verify and calibrate our findings.
format Online
Article
Text
id pubmed-9581225
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95812252022-10-20 A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft Fan, Ning Wang, Tianyi Wang, Aobo Yuan, Shuo Du, Peng Si, Fangda Zhu, Wenyi Li, Jian Zang, Lei Front Surg Surgery BACKGROUND: For patients with osteoporotic vertebral compression fractures (OVCFs) treated with percutaneous kyphoplasty (PKP), the occurrence and risk factors of intradiscal cement leakage should be characteristic of the presence of intravertebral cleft (IVC). This study aimed to identify risk factors for intradiscal leakage in individuals with OVCFs combined with IVC treated with PKP and build a powered and well-calibrated predictive nomogram. METHODS: This study retrospectively reviewed consecutive patients who underwent PKP at our center between January 2016 and May 2021. Patients diagnosed with OVCFs combined with IVC were identified, and the incidence of different types of bone cement leakage was recorded. Risk factors for intradiscal leakage among the demographic, perioperative baseline, and radiologic data were identified, following which a nomogram was developed and verified. RESULTS: A total of 109 eligible patients were included, and the intradiscal leakage rate was 32.1%. Compression rate (odds ratio [OR] 0.025; 95% confidence interval [CI] 0.002–0.264; P = 0.002) and cemented vertebral body fraction (OR 44.122; 95% CI 2.790–697.740; P = 0.007) were identified as independent risk factors. A predictive nomogram with good predictive power (C-statistic = 0.786) and fitness of data (Hosmer–Lemeshow goodness-of-fit test, P = 0.092) was established to build a quantitative relationship between the risk factors and intradiscal leakage. CONCLUSION: The incidence rate of intradiscal leakage in PKP for OVCFs combined with IVC was 32.1%. Compression rate and cemented vertebral body fraction were identified as independent risk factors. A powered and well-calibrated nomogram was established to accurately predict the probability of intradiscal leakage. Further prospective and multicenter studies are required to verify and calibrate our findings. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9581225/ /pubmed/36277280 http://dx.doi.org/10.3389/fsurg.2022.1005220 Text en © 2022 Fan, Wang, Wang, Yuan, Du, Si, Zhu, Li and Zang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Fan, Ning
Wang, Tianyi
Wang, Aobo
Yuan, Shuo
Du, Peng
Si, Fangda
Zhu, Wenyi
Li, Jian
Zang, Lei
A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title_full A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title_fullStr A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title_full_unstemmed A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title_short A predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
title_sort predictive nomogram for intradiscal cement leakage in percutaneous kyphoplasty for osteoporotic vertebral compression fractures combined with intravertebral cleft
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581225/
https://www.ncbi.nlm.nih.gov/pubmed/36277280
http://dx.doi.org/10.3389/fsurg.2022.1005220
work_keys_str_mv AT fanning apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT wangtianyi apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT wangaobo apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT yuanshuo apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT dupeng apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT sifangda apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT zhuwenyi apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT lijian apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT zanglei apredictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT fanning predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT wangtianyi predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT wangaobo predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT yuanshuo predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT dupeng predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT sifangda predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT zhuwenyi predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT lijian predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft
AT zanglei predictivenomogramforintradiscalcementleakageinpercutaneouskyphoplastyforosteoporoticvertebralcompressionfracturescombinedwithintravertebralcleft