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The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes th...

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Autores principales: Gao, Song, Jiang, Xingyue, Wang, Liang, Jiang, Shanshan, Luo, Hanyuan, Chen, Yan, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581229/
https://www.ncbi.nlm.nih.gov/pubmed/36278230
http://dx.doi.org/10.3389/fphar.2022.1029601
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author Gao, Song
Jiang, Xingyue
Wang, Liang
Jiang, Shanshan
Luo, Hanyuan
Chen, Yan
Peng, Cheng
author_facet Gao, Song
Jiang, Xingyue
Wang, Liang
Jiang, Shanshan
Luo, Hanyuan
Chen, Yan
Peng, Cheng
author_sort Gao, Song
collection PubMed
description Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes the main pathogenic factors involved in the development of liver cancer, including metabolic fatty liver disease, viral infection, and alcoholic cirrhosis, and focuses on the mechanism of action of bioactive components such as polysaccharides, alkaloids, phenols, peptides, and active bacteria/fungi. In addition, we also summarize transformation methods, combined therapy and modification of bioactive substances to improve the treatment efficiency against liver cancer, highlighting new ideas in this field.
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spelling pubmed-95812292022-10-20 The pathogenesis of liver cancer and the therapeutic potential of bioactive substances Gao, Song Jiang, Xingyue Wang, Liang Jiang, Shanshan Luo, Hanyuan Chen, Yan Peng, Cheng Front Pharmacol Pharmacology Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes the main pathogenic factors involved in the development of liver cancer, including metabolic fatty liver disease, viral infection, and alcoholic cirrhosis, and focuses on the mechanism of action of bioactive components such as polysaccharides, alkaloids, phenols, peptides, and active bacteria/fungi. In addition, we also summarize transformation methods, combined therapy and modification of bioactive substances to improve the treatment efficiency against liver cancer, highlighting new ideas in this field. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9581229/ /pubmed/36278230 http://dx.doi.org/10.3389/fphar.2022.1029601 Text en Copyright © 2022 Gao, Jiang, Wang, Jiang, Luo, Chen and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gao, Song
Jiang, Xingyue
Wang, Liang
Jiang, Shanshan
Luo, Hanyuan
Chen, Yan
Peng, Cheng
The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title_full The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title_fullStr The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title_full_unstemmed The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title_short The pathogenesis of liver cancer and the therapeutic potential of bioactive substances
title_sort pathogenesis of liver cancer and the therapeutic potential of bioactive substances
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581229/
https://www.ncbi.nlm.nih.gov/pubmed/36278230
http://dx.doi.org/10.3389/fphar.2022.1029601
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