Cargando…

Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy

This manuscript explores a method of benchmarking antimicrobial use within the context of farm level therapeutic incidence (a proxy for disease incidence), and the outcome of that therapy. This is reported both within the same farm over time (2016–2019), as well as evaluated across participating far...

Descripción completa

Detalles Bibliográficos
Autores principales: Schrag, Nora F. D., Godden, Sandra M., Singer, Randall S., Lombard, Jason E., Wenz, John R., Amrine, David E., Lubbers, Brian V., Apley, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581275/
https://www.ncbi.nlm.nih.gov/pubmed/36277073
http://dx.doi.org/10.3389/fvets.2022.1022557
_version_ 1784812585789423616
author Schrag, Nora F. D.
Godden, Sandra M.
Singer, Randall S.
Lombard, Jason E.
Wenz, John R.
Amrine, David E.
Lubbers, Brian V.
Apley, Michael D.
author_facet Schrag, Nora F. D.
Godden, Sandra M.
Singer, Randall S.
Lombard, Jason E.
Wenz, John R.
Amrine, David E.
Lubbers, Brian V.
Apley, Michael D.
author_sort Schrag, Nora F. D.
collection PubMed
description This manuscript explores a method of benchmarking antimicrobial use within the context of farm level therapeutic incidence (a proxy for disease incidence), and the outcome of that therapy. This is reported both within the same farm over time (2016–2019), as well as evaluated across participating farms. Reporting antimicrobial use in this format addresses multiple primary questions necessary for evaluating on farm antimicrobial stewardship: How much disease is recorded? How much antimicrobial use is recorded? How often are antimicrobials included in therapy for each disease? What is the outcome of therapy? The three primary metrics reported are: therapeutic events per 100 cow years (TE/100CY), antimicrobial regimens per 100 cow years (REG/100CY), and the percent therapeutic success (% Success). Success was defined as: the cow remained in the herd and had no further TE recorded within 30 days of the end of the TE being evaluated. These measures identify opportunities for change on an individual farm, such as improvement in disease prevention, or a change in choices about when to include an antimicrobial in the treatment protocol. Therapeutic outcomes provide additional context, in some instances demonstrating differences in recording practices and case definitions, while in other cases serving to safeguard animal welfare as efforts are made to decrease antimicrobial use in the future. Although developed for farm level reporting, the metrics may also be more broadly summarized to meet future reporting requirements for marketing chain or national level antimicrobial use reports. The process outlined here serves as a prototype to be considered when developing antimicrobial use reporting systems where farm level antimicrobial stewardship is the primary objective.
format Online
Article
Text
id pubmed-9581275
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95812752022-10-20 Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy Schrag, Nora F. D. Godden, Sandra M. Singer, Randall S. Lombard, Jason E. Wenz, John R. Amrine, David E. Lubbers, Brian V. Apley, Michael D. Front Vet Sci Veterinary Science This manuscript explores a method of benchmarking antimicrobial use within the context of farm level therapeutic incidence (a proxy for disease incidence), and the outcome of that therapy. This is reported both within the same farm over time (2016–2019), as well as evaluated across participating farms. Reporting antimicrobial use in this format addresses multiple primary questions necessary for evaluating on farm antimicrobial stewardship: How much disease is recorded? How much antimicrobial use is recorded? How often are antimicrobials included in therapy for each disease? What is the outcome of therapy? The three primary metrics reported are: therapeutic events per 100 cow years (TE/100CY), antimicrobial regimens per 100 cow years (REG/100CY), and the percent therapeutic success (% Success). Success was defined as: the cow remained in the herd and had no further TE recorded within 30 days of the end of the TE being evaluated. These measures identify opportunities for change on an individual farm, such as improvement in disease prevention, or a change in choices about when to include an antimicrobial in the treatment protocol. Therapeutic outcomes provide additional context, in some instances demonstrating differences in recording practices and case definitions, while in other cases serving to safeguard animal welfare as efforts are made to decrease antimicrobial use in the future. Although developed for farm level reporting, the metrics may also be more broadly summarized to meet future reporting requirements for marketing chain or national level antimicrobial use reports. The process outlined here serves as a prototype to be considered when developing antimicrobial use reporting systems where farm level antimicrobial stewardship is the primary objective. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9581275/ /pubmed/36277073 http://dx.doi.org/10.3389/fvets.2022.1022557 Text en Copyright © 2022 Schrag, Godden, Singer, Lombard, Wenz, Amrine, Lubbers and Apley. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Schrag, Nora F. D.
Godden, Sandra M.
Singer, Randall S.
Lombard, Jason E.
Wenz, John R.
Amrine, David E.
Lubbers, Brian V.
Apley, Michael D.
Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title_full Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title_fullStr Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title_full_unstemmed Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title_short Improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
title_sort improving farm-level antimicrobial stewardship benchmarks by reporting antimicrobial use within the context of both the magnitude of disease pressure and the outcome of therapy
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581275/
https://www.ncbi.nlm.nih.gov/pubmed/36277073
http://dx.doi.org/10.3389/fvets.2022.1022557
work_keys_str_mv AT schragnorafd improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT goddensandram improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT singerrandalls improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT lombardjasone improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT wenzjohnr improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT amrinedavide improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT lubbersbrianv improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy
AT apleymichaeld improvingfarmlevelantimicrobialstewardshipbenchmarksbyreportingantimicrobialusewithinthecontextofboththemagnitudeofdiseasepressureandtheoutcomeoftherapy