Studies toward synthesis of the core skeleton of spiroaspertrione A

Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[...

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Detalles Bibliográficos
Autores principales: Shen, Zhong-Hui, Lu, Si-Yuan, Zheng, Jing-Yun, Zhang, Xiang-Zhi, Peng, Jin-Bao, Ma, Ai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581311/
https://www.ncbi.nlm.nih.gov/pubmed/36277342
http://dx.doi.org/10.3389/fchem.2022.1022533
Descripción
Sumario:Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.

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