Studies toward synthesis of the core skeleton of spiroaspertrione A

Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[...

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Autores principales: Shen, Zhong-Hui, Lu, Si-Yuan, Zheng, Jing-Yun, Zhang, Xiang-Zhi, Peng, Jin-Bao, Ma, Ai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581311/
https://www.ncbi.nlm.nih.gov/pubmed/36277342
http://dx.doi.org/10.3389/fchem.2022.1022533
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author Shen, Zhong-Hui
Lu, Si-Yuan
Zheng, Jing-Yun
Zhang, Xiang-Zhi
Peng, Jin-Bao
Ma, Ai-Jun
author_facet Shen, Zhong-Hui
Lu, Si-Yuan
Zheng, Jing-Yun
Zhang, Xiang-Zhi
Peng, Jin-Bao
Ma, Ai-Jun
author_sort Shen, Zhong-Hui
collection PubMed
description Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.
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spelling pubmed-95813112022-10-20 Studies toward synthesis of the core skeleton of spiroaspertrione A Shen, Zhong-Hui Lu, Si-Yuan Zheng, Jing-Yun Zhang, Xiang-Zhi Peng, Jin-Bao Ma, Ai-Jun Front Chem Chemistry Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed. Frontiers Media S.A. 2022-10-05 /pmc/articles/PMC9581311/ /pubmed/36277342 http://dx.doi.org/10.3389/fchem.2022.1022533 Text en Copyright © 2022 Shen, Lu, Zheng, Zhang, Peng and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Shen, Zhong-Hui
Lu, Si-Yuan
Zheng, Jing-Yun
Zhang, Xiang-Zhi
Peng, Jin-Bao
Ma, Ai-Jun
Studies toward synthesis of the core skeleton of spiroaspertrione A
title Studies toward synthesis of the core skeleton of spiroaspertrione A
title_full Studies toward synthesis of the core skeleton of spiroaspertrione A
title_fullStr Studies toward synthesis of the core skeleton of spiroaspertrione A
title_full_unstemmed Studies toward synthesis of the core skeleton of spiroaspertrione A
title_short Studies toward synthesis of the core skeleton of spiroaspertrione A
title_sort studies toward synthesis of the core skeleton of spiroaspertrione a
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581311/
https://www.ncbi.nlm.nih.gov/pubmed/36277342
http://dx.doi.org/10.3389/fchem.2022.1022533
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