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Prioritizing interventions for preventing COVID-19 outbreaks in military basic training

Like other congregate living settings, military basic training has been subject to outbreaks of COVID-19. We sought to identify improved strategies for preventing outbreaks in this setting using an agent-based model of a hypothetical cohort of trainees on a U.S. Army post. Our analysis revealed uniq...

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Autores principales: España, Guido, Perkins, T. Alex, Pollett, Simon D., Smith, Morgan E., Moore, Sean M., Kwon, Paul O., Hall, Tara L., Beagle, Milford H., Murray, Clinton K., Hakre, Shilpa, Peel, Sheila A., Modjarrad, Kayvon, Scott, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581358/
https://www.ncbi.nlm.nih.gov/pubmed/36206315
http://dx.doi.org/10.1371/journal.pcbi.1010489
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author España, Guido
Perkins, T. Alex
Pollett, Simon D.
Smith, Morgan E.
Moore, Sean M.
Kwon, Paul O.
Hall, Tara L.
Beagle, Milford H.
Murray, Clinton K.
Hakre, Shilpa
Peel, Sheila A.
Modjarrad, Kayvon
Scott, Paul T.
author_facet España, Guido
Perkins, T. Alex
Pollett, Simon D.
Smith, Morgan E.
Moore, Sean M.
Kwon, Paul O.
Hall, Tara L.
Beagle, Milford H.
Murray, Clinton K.
Hakre, Shilpa
Peel, Sheila A.
Modjarrad, Kayvon
Scott, Paul T.
author_sort España, Guido
collection PubMed
description Like other congregate living settings, military basic training has been subject to outbreaks of COVID-19. We sought to identify improved strategies for preventing outbreaks in this setting using an agent-based model of a hypothetical cohort of trainees on a U.S. Army post. Our analysis revealed unique aspects of basic training that require customized approaches to outbreak prevention, which draws attention to the possibility that customized approaches may be necessary in other settings, too. In particular, we showed that introductions by trainers and support staff may be a major vulnerability, given that those individuals remain at risk of community exposure throughout the training period. We also found that increased testing of trainees upon arrival could actually increase the risk of outbreaks, given the potential for false-positive test results to lead to susceptible individuals becoming infected in group isolation and seeding outbreaks in training units upon release. Until an effective transmission-blocking vaccine is adopted at high coverage by individuals involved with basic training, need will persist for non-pharmaceutical interventions to prevent outbreaks in military basic training. Ongoing uncertainties about virus variants and breakthrough infections necessitate continued vigilance in this setting, even as vaccination coverage increases.
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spelling pubmed-95813582022-10-20 Prioritizing interventions for preventing COVID-19 outbreaks in military basic training España, Guido Perkins, T. Alex Pollett, Simon D. Smith, Morgan E. Moore, Sean M. Kwon, Paul O. Hall, Tara L. Beagle, Milford H. Murray, Clinton K. Hakre, Shilpa Peel, Sheila A. Modjarrad, Kayvon Scott, Paul T. PLoS Comput Biol Research Article Like other congregate living settings, military basic training has been subject to outbreaks of COVID-19. We sought to identify improved strategies for preventing outbreaks in this setting using an agent-based model of a hypothetical cohort of trainees on a U.S. Army post. Our analysis revealed unique aspects of basic training that require customized approaches to outbreak prevention, which draws attention to the possibility that customized approaches may be necessary in other settings, too. In particular, we showed that introductions by trainers and support staff may be a major vulnerability, given that those individuals remain at risk of community exposure throughout the training period. We also found that increased testing of trainees upon arrival could actually increase the risk of outbreaks, given the potential for false-positive test results to lead to susceptible individuals becoming infected in group isolation and seeding outbreaks in training units upon release. Until an effective transmission-blocking vaccine is adopted at high coverage by individuals involved with basic training, need will persist for non-pharmaceutical interventions to prevent outbreaks in military basic training. Ongoing uncertainties about virus variants and breakthrough infections necessitate continued vigilance in this setting, even as vaccination coverage increases. Public Library of Science 2022-10-07 /pmc/articles/PMC9581358/ /pubmed/36206315 http://dx.doi.org/10.1371/journal.pcbi.1010489 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
España, Guido
Perkins, T. Alex
Pollett, Simon D.
Smith, Morgan E.
Moore, Sean M.
Kwon, Paul O.
Hall, Tara L.
Beagle, Milford H.
Murray, Clinton K.
Hakre, Shilpa
Peel, Sheila A.
Modjarrad, Kayvon
Scott, Paul T.
Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title_full Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title_fullStr Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title_full_unstemmed Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title_short Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
title_sort prioritizing interventions for preventing covid-19 outbreaks in military basic training
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9581358/
https://www.ncbi.nlm.nih.gov/pubmed/36206315
http://dx.doi.org/10.1371/journal.pcbi.1010489
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